Epoxy Fluor 7
- Product Name
- Epoxy Fluor 7
- CAS No.
- 863223-43-2
- Chemical Name
- Epoxy Fluor 7
- Synonyms
- Epoxy Fluor 7;Epoxy Fluor 7 Exclusive;Cyano(6-methoxy-2-napthalenyl)methyl[(2,3)-3-phenyloxiranyl]methyl ester;[cyano-(6-methoxynaphthalen-2-yl)methyl] (3-phenyloxiran-2-yl)methyl carbonate;Carbonic acid, cyano(6-methoxy-2-naphthalenyl)methyl [(2R,3R)-3-phenyl-2-oxiranyl]methyl ester, rel-
- CBNumber
- CB02590956
- Molecular Formula
- C23H19NO5
- Formula Weight
- 389.4
- MOL File
- 863223-43-2.mol
Epoxy Fluor 7 Property
- storage temp.
- Store at -20°C,protect from light
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
- form
- A crystalline solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 10008610
- Product name
- Epoxy Fluor 7
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 10008610
- Product name
- Epoxy Fluor 7
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2024/03/01
- Product number
- 10008610
- Product name
- Epoxy Fluor 7
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $299
- Updated
- 2024/03/01
- Product number
- 10008610
- Product name
- Epoxy Fluor 7
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $1498
- Updated
- 2023/06/20
- Product number
- 1692AH
- Product name
- Cyano(6-methoxy-2-napthalenyl)methyl[(2,3)-3-phenyloxiranyl]methylester,carbonicacid
- Packaging
- 5mg
- Price
- $318
- Updated
- 2021/12/16
Epoxy Fluor 7 Chemical Properties,Usage,Production
Description
Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids (EpETrEs) to the corresponding DiHETrEs thereby diminishing their vasodilator activity.1 Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation.2,3 Epoxy fluor 7 is a sensitive fluorescent substrate for soluble epoxide hydrolase (sEH) that can be used to monitor the activity of both human and mouse enzymes.4 Hydrolysis of the substrate epoxide yields a highly fluorescent product that can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. Epoxy fluor 7 is more stable in aqueous solution and offers about 2-
Uses
Epoxy Fluor 7 is a sensitive fluorescent substrate for soluble epoxide hydrolase (sEH) that can be used for human and mouse enzymes. Epoxy Fluor 7 is hydrolyzed to yield fluorescence used for monitoring the activity of sEH.
References
1. Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids Circ. Res. 87(11),992-998(2000).
2. Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-
3. Schmelzer, K.R., Kubala, L., Newman, J.W., et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation Proc. Natl. Acad. Sci. USA 102(28),9772-9777(2005).
4. Jones, P.D., Wolf, N.M., Morisseau, C., et al. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies Anal. Biochem. 343,66-75(2005).
Epoxy Fluor 7 Preparation Products And Raw materials
Raw materials
Preparation Products
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