Resorcinolnaphthalein

Product Name: Resorcinolnaphthalein
CAS No.: 41307-63-5
Chemical Name: Resorcinolnaphthalein
Synonyms: Resorcinolnaphthalein;FTUOFHGOGJGQAB-UHFFFAOYSA-N;Resorcinolnaphthalein, 10 mM in DMSO;Spiro[1H,3H-naphtho[1,8-cd]pyran-1,9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-;fibrosis,ACE2,hypertension,renal,perivascular,Resorcinolnaphthalein,reversal,inhibit,myocardial,Inhibitor,Angiotensin-converting Enzyme (ACE)
CBNumber: CB02592374
Molecular Formula: C24H14O5
Formula Weight: 382.36
MOL File: 41307-63-5.mol

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Resorcinolnaphthalein Property

Melting point:: >290 °C
Boiling point:: 688.4±55.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form: crystalline solid
pka: 9.13±0.20(Predicted)
color: Light yellow to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13082
Product name: Resorcinolnaphthalein
Purity: ≥98%
Packaging: 5mg
Price: $21
Updated: 2024/03/01

Cayman Chemical

Product number: 13082
Product name: Resorcinolnaphthalein
Purity: ≥98%
Packaging: 10mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 13082
Product name: Resorcinolnaphthalein
Purity: ≥98%
Packaging: 50mg
Price: $157
Updated: 2024/03/01

Cayman Chemical

Product number: 13082
Product name: Resorcinolnaphthalein
Purity: ≥98%
Packaging: 100mg
Price: $274
Updated: 2024/03/01

ApexBio Technology

Product number: C3931
Product name: Resorcinolnaphthalein
Packaging: 100mg
Price: $311
Updated: 2021/12/16

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Resorcinolnaphthalein Chemical Properties,Usage,Production

Uses

Angiotensin-converting enzyme 2 (ACE2) is an enzyme that is cardioprotective and renoprotective. Resorcinolnaphthalein increases the activity of ACE2 in vitro (EC50 = 19.5 μM). Activation of ACE2 in rats produces a decrease in blood pressure and improvement in cardiac function. In spontaneously hypertensive rats it produces a reversal of myocardial, perivascular, and renal fibrosis.[Cayman Chemical]

Biological Activity

resorcinolnaphthalein is an angiotensin-converting enzyme 2 (ace2) activator [1].angiotensin-converting enzyme 2 (ace2) has been involved in hydrolyzing angiotensin ii and opposing its actions, and plays a protective role in the pathogenesis of pulmonary arterial hypertension (pah) [2]. targeted disruption of ace2 in mice results in a severe cardiac contractility defect, increased angiotensin ii levels, and upregulation of hypoxia-induced genes in the heart [2].

in vitro

resorcinolnaphthalein enhanced ace2 activity in a dose-dependent manner [1].

in vivo

resorcinolnaphthalein caused significant activation of ace2 in both normal and diseased rats in 7 days after treatment. treatment with resorcinolnaphthalein prevented high pap, right ventricular hypertrophy and neointimal formation. resorcinolnaphthalein caused an improved endothelia-dependent vasorelaxation and decreased in proinflammatory cytokines, such as tnf-α, mcp-1, il-6, and increased in anti-inflammatory cytokine il-10 in the early stage of the pathogenesis [3]. resorcinolnaphthalein can specifically and effectively enhanced ace2 activity in rats [4]. ace2 activation by resorcinolnaphthalein showed effects on pulmonary endothelial dysfunction and neointimal formation during the development of severe pah in rats [4].

References

[1] prada j a h, ferreira a j, katovich m j, et al. structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents[j]. hypertension, 2008, 51(5): 1312-1317.
[2] crackower m a, sarao r, oudit g y, et al. angiotensin-converting enzyme 2 is an essential regulator of heart function[j]. nature, 2002, 417(6891): 822-828.
[3] haber p k, ye m, wysocki j, et al. angiotensin-converting enzyme 2–independent action of presumed angiotensin-converting enzyme 2 activatorsnovelty and significance[j]. hypertension, 2014, 63(4): 774-782.
[4] li g, liu y, zhu y, et al. ace2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats[j]. lung, 2013, 191(4): 327-336.

Resorcinolnaphthalein Preparation Products And Raw materials

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Preparation Products

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41307-63-5, ResorcinolnaphthaleinRelated Search:

Resorcinolnaphthalein

FTUOFHGOGJGQAB-UHFFFAOYSA-N

fibrosis,ACE2,hypertension,renal,perivascular,Resorcinolnaphthalein,reversal,inhibit,myocardial,Inhibitor,Angiotensin-converting Enzyme (ACE)

Spiro[1H,3H-naphtho[1,8-cd]pyran-1,9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-

Resorcinolnaphthalein, 10 mM in DMSO

41307-63-5