1-(2-broMo-1-fluoroethyl)benzene
- Product Name
- 1-(2-broMo-1-fluoroethyl)benzene
- CAS No.
- 1786-36-3
- Chemical Name
- 1-(2-broMo-1-fluoroethyl)benzene
- Synonyms
- (2-Bromo-1-fluoroethyl);(2-BroMo-1-fluoroethyl)benzene;1-(2-broMo-1-fluoroethyl)benzene;Benzene, (2-bromo-1-fluoroethyl)-
- CBNumber
- CB02592970
- Molecular Formula
- C8H8BrF
- Formula Weight
- 203.05
- MOL File
- 1786-36-3.mol
1-(2-broMo-1-fluoroethyl)benzene Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Safety
- HS Code
- 2902900000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- HCH0363103
- Product name
- (2-BROMO-1-FLUOROETHYL)BENZENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.34
- Updated
- 2021/12/16
- Product number
- PC400563
- Product name
- (2-Bromo-1-fluoroethyl)benzene
- Packaging
- 1g
- Price
- $870
- Updated
- 2021/12/16
- Product number
- 9366AA
- Product name
- (2-Bromo-1-fluoroethyl)benzene
- Packaging
- 100mg
- Price
- $215
- Updated
- 2021/12/16
- Product number
- 118232
- Product name
- (2-Bromo-1-fluoroethyl)benzene
- Packaging
- 5g
- Price
- $3791
- Updated
- 2021/12/16
- Product number
- 1786363
- Product name
- (2-Bromo-1-fluoroethyl)benzene
- Packaging
- 250mg
- Price
- $185.41
- Updated
- 2021/12/16
1-(2-broMo-1-fluoroethyl)benzene Chemical Properties,Usage,Production
Uses
(2-Bromo-1-fluoroethyl)benzene is used as a reactant in the bromofluorination of alkenes with N-bromosuccinimide combined with triethylamine tris(hydrofluoride).
Synthesis
292638-84-7
1786-36-3
The general procedure for the synthesis of (2-bromo-1-fluoro)ethylbenzene from the compound (CAS: 292638-84-7) was as follows: the reaction was carried out in a plastic vial. N-bromosuccinimide (NBS, 53.4 mg, 0.3 mmol) and olefin (0.20 mmol) were dissolved in dichloromethane (CH2Cl2, 1 mL) followed by addition of DMPU/HF (41.2 μL, 1.4 mmol). The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (2 mL) and the mixture was extracted with dichloromethane (3 x 2 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. In some cases, purification by rapid chromatography on silica gel (SiO2) (eluent ratio 9:1 hexane/ethyl acetate) yields a mixture of bromofluorine compounds as regional isomers. The structure of (2-bromo-1-fluoroethyl)benzene (2a) was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, CDCl3) and fluorine spectroscopy (19F NMR, 376 MHz, CDCl3) with the following data: 1H NMR δ 7.50 (m, 5H), 5.60 (dd, J = 47.1, 7.8, 4.1 Hz, 1H). 3.66 (ddd, J = 15.3, 11.3, 7.8 Hz, 1H), 3.58 (ddd, J = 26.0, 11.3, 4.2 Hz, 1H); 19F NMR δ -175.0 (m). The product was a colorless oil.
References
[1] Synthesis, 2000, # 10, p. 1479 - 1490
[2] Tetrahedron, 1990, vol. 46, # 12, p. 4255 - 4260
[3] Journal of Fluorine Chemistry, 2017, vol. 203, p. 136 - 139
[4] Journal of Organic Chemistry, 2009, vol. 74, # 21, p. 8377 - 8380
[5] Tetrahedron Letters, 1991, vol. 32, # 9, p. 1215 - 1218
1-(2-broMo-1-fluoroethyl)benzene Preparation Products And Raw materials
Raw materials
Preparation Products
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