6-Chloro-5-fluoro-pyridine-2-carboxylic acid
- Product Name
- 6-Chloro-5-fluoro-pyridine-2-carboxylic acid
- CAS No.
- 860296-24-8
- Chemical Name
- 6-Chloro-5-fluoro-pyridine-2-carboxylic acid
- Synonyms
- 6-Chloro-5-fluoropicolinic acid;2-Chloro-3-fluoro-6-carboxypyridine;6-Chloro-5-fluoro-2-pyridinecarboxylic acid;6-Chloro-5-fluoro-pyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 6-chloro-5-fluoro-;6-Chloro-5-fluoropyridine-2-carboxylic acid AldrichCPR
- CBNumber
- CB02595274
- Molecular Formula
- C6H3ClFNO2
- Formula Weight
- 175.54
- MOL File
- 860296-24-8.mol
6-Chloro-5-fluoro-pyridine-2-carboxylic acid Property
- Melting point:
- 193-195 °C(Solv: heptane (142-82-5))
- Boiling point:
- 310.3±37.0 °C(Predicted)
- Density
- 1.576±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.21±0.10(Predicted)
- form
- Solid
- color
- Off-white
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C6H3ClFNO2/c7-5-3(8)1-2-4(9-5)6(10)11/h1-2H,(H,10,11)
- InChIKey
- JHFKXHUKNYFWJM-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC(Cl)=C(F)C=C1
- CAS DataBase Reference
- 860296-24-8
Safety
- WGK Germany
- 3
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- MNO000118
- Product name
- 6-Chloro-5-fluoropyridine-2-carboxylic acid
- Purity
- AldrichCPR
- Packaging
- 1g
- Price
- $259
- Updated
- 2025/07/31
- Product number
- C584718
- Product name
- 6-Chloro-5-fluoropicolinicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 067071
- Product name
- 6-Chloro-5-fluoropyridine-2-carboxylic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $42
- Updated
- 2021/12/16
- Product number
- 3423AC
- Product name
- 6-Chloro-5-fluoropicolinicacid
- Packaging
- 250mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- 3423AC
- Product name
- 6-Chloro-5-fluoropicolinicacid
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
6-Chloro-5-fluoro-pyridine-2-carboxylic acid Chemical Properties,Usage,Production
Uses
It is an important intermediate for pharmaceutical.
Synthesis
1214337-05-9
860296-24-8
Step 3: Synthesis of 6-chloro-5-fluoropyridinecarboxylic acid Methyl 6-chloro-5-fluoropyridinecarboxylate (1.35 g, 7.095 mmol) was dissolved in a solvent mixture of THF and H2O (6:1, 42 mL, v/v), followed by addition of lithium hydroxide monohydrate (596 mg, 14.19 mmol). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure, distilled water (20 mL) was added to dissolve the residue, and the solution was acidified by slow dropwise addition of 1N HCl aqueous solution. The acidified solution was extracted with 5% MeOH/MC (30 mL × 2). The organic layers were combined, dried with anhydrous sodium sulfate, filtered, concentrated and dried under vacuum to give 1.04 g of white solid product in 80% yield.
References
[1] Patent: WO2011/139107, 2011, A2. Location in patent: Page/Page column 83-84
6-Chloro-5-fluoro-pyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
6-Chloro-5-fluoro-pyridine-2-carboxylic acid Suppliers
- Tel
- 15221991309
- 315346700@qq.com
- Country
- China
- ProdList
- 97
- Advantage
- 58
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 025-52161033 15312098939
- Fax
- 025-83254025
- sales@njdrschem.com
- Country
- China
- ProdList
- 578
- Advantage
- 64
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- 029-86115547 17791676824
- Fax
- 02151602123
- sales@cochemical.com
- Country
- China
- ProdList
- 3014
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8144
- Advantage
- 55
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
View Lastest Price from 6-Chloro-5-fluoro-pyridine-2-carboxylic acid manufacturers
- Product
- 6-Chloro-5-fluoro-pyridine-2-carboxylic acid 860296-24-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-24