ChemicalBook > CAS DataBase List > O-TOLUENESULFONYL CHLORIDE

O-TOLUENESULFONYL CHLORIDE

Product Name
O-TOLUENESULFONYL CHLORIDE
CAS No.
133-59-5
Chemical Name
O-TOLUENESULFONYL CHLORIDE
Synonyms
2-METHYLBENZENESULFONYL CHLORIDE;o-Toluenesulfochloride;o-tosylchloride;o-Tosyl chloride;Paroxetine Impurity 30;o-tolylsulfonylchloride;containsca23%isomer)75+%;2-TOLUENESULFONYL CHLORIDE;O-TOLUENESULFONYL CHLORIDE;ortho-toluenesulfochloride
CBNumber
CB0259602
Molecular Formula
C7H7ClO2S
Formula Weight
190.65
MOL File
133-59-5.mol
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O-TOLUENESULFONYL CHLORIDE Property

Melting point:
10°C
Boiling point:
254 °C(lit.)
Density 
1.320 g/mL at 25 °C(lit.)
refractive index 
n20/D >1.5580(lit.)
Flash point:
>230 °F
storage temp. 
Store under inert gas
solubility 
Acetonitrile (Slightly), Chloroform(Slightly)
form 
clear liquid
color 
Colorless to Light yellow
Water Solubility 
Soluble in hot alcohol, ether and benzene. Reacts with water.
Sensitive 
Moisture Sensitive
BRN 
973180
InChI
InChI=1S/C7H7ClO2S/c1-6-4-2-3-5-7(6)11(8,9)10/h2-5H,1H3
InChIKey
HDECRAPHCDXMIJ-UHFFFAOYSA-N
SMILES
C1(S(Cl)(=O)=O)=CC=CC=C1C
CAS DataBase Reference
133-59-5(CAS DataBase Reference)
EPA Substance Registry System
Benzenesulfonyl chloride, 2-methyl- (133-59-5)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
Hazard Note 
Corrosive
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
2904100090
Hazardous Substances Data
133-59-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
557323
Product name
o-Toluenesulfonyl chloride
Purity
97%
Packaging
1g
Price
$33.4
Updated
2022/05/15
Sigma-Aldrich
Product number
557323
Product name
o-Toluenesulfonyl chloride
Purity
97%
Packaging
5g
Price
$87.7
Updated
2022/05/15
TCI Chemical
Product number
T0284
Product name
o-Toluenesulfonyl Chloride (contains ca. 23% isomer)
Purity
>75.0%(GC)
Packaging
25g
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
T0284
Product name
o-Toluenesulfonyl Chloride (contains ca. 23% isomer)
Purity
>75.0%(GC)
Packaging
500g
Price
$225
Updated
2025/07/31
Usbiological
Product number
461369
Product name
o-Toluenesulfonyl Chloride
Packaging
1g
Price
$319
Updated
2021/12/16
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O-TOLUENESULFONYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Oily liquid. Melting point 10.2°C, boiling point 154°C (4.8kPa), 126°C (1.33kPa), relative density 1.3383 (20/4°C), refractive index 1.5565. soluble in hot alcohols, ethers, benzene, insoluble in water.

Uses

o-Toluenesulfonyl chloride is used in organic synthesis and saccharin production. It is also used as pharmaceutical intermediate.

Uses

o-Toluenesulfonyl chloride may be used in the synthesis of:

  • oxazoline
  • mesityl o-tolyl sulfone
  • allyl o-toluenesulfonate
  • 2-methyl-4′-t-butyldiphenyl sulfone

General Description

o-Toluenesulfonyl chloride can be synthesized by reacting o-thiocresol in glacial acetic acid with chlorine. It participates in the preparation of 5-chloro-3-phenyl-2,1-benzisoxazole.

O-TOLUENESULFONYL CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

2-Methylbenzene-1-sulfonamide Tosyl chloride Saccharin sodium
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O-TOLUENESULFONYL CHLORIDE Suppliers

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View Lastest Price from O-TOLUENESULFONYL CHLORIDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
o-Toluenesulfonyl chloride 133-59-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-02
Hebei Chuanghai Biotechnology Co,.LTD
Product
O-TOLUENESULFONYL CHLORIDE 133-59-5
Price
US $9.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000kg
Release date
2024-08-23
Henan Fengda Chemical Co., Ltd
Product
O-TOLUENESULFONYL CHLORIDE 133-59-5
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-24

133-59-5, O-TOLUENESULFONYL CHLORIDERelated Search:

Tosyl chloride 2-Methylbenzene-1-sulfonamide Mesitylene-2-sulfonyl chloride Methyl 2-(chlorosulfonyl)benzoate 4-CHLORO-2,5-DIMETHYLBENZENESULFONYL CHLORIDE 5-NITRO-O-TOLUENESULFONYL CHLORIDE 4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL CHLORIDE 1,2-NAPHTHOQUINONE-2-DIAZIDO-5-SULFONYL CHLORIDE 2-(Trifluoromethyl)benzenesulfonyl chloride 2,4-MESITYLENEDISULFONYL DICHLORIDE 2-Cyanobenzenesulphonyl chloride 2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONYL CHLORIDE 2,3,5,6-TETRAMETHYLBENZENESULFONYL CHLORIDE 2-CHLORO-6-METHYLBENZENESULFONYL CHLORIDE O-TOLUENESULFONYL CHLORIDE 2,5-DIMETHYLBENZENESULFONYL CHLORIDE 3-CHLORO-2-METHYLBENZENESULFONYL CHLORIDE 3,4-Dichloro-alpha-toluenesulfonyl chloride

  • ortho-toluenesulfonylchloride
  • o-Toluenesulfochloride
  • o-tolylsulfonylchloride
  • o-Tosyl chloride
  • o-tosylchloride
  • toluene-2-sulphonylchloride
  • ortho-toluenesulfonchloride
  • o-Toluenesulphonyl chloride
  • containsca23%isomer)75+%
  • o-Toluenesulfonyl Chloride (contains ca. 23% isomer)
  • 2-Methylbenzenesulfonic acid chloride
  • o-Toluenesulphonyl chloride, 2-(Chlorosulphonyl)toluene
  • o-Toluenesulfonyl chloride 97%
  • <i>o</i>-Toluenesulfonyl Chloride (contains <i>ca</i>. 23% isomer)
  • 2-METHYLBENZENESULPHONYL CHLORIDE
  • 2-METHYLBENZENESULFONYL CHLORIDE
  • 2-TOLUENESULFONYL CHLORIDE
  • O-TOLUENESULFONYL CHLORIDE
  • 2-methyl-benzenesulfonylchlorid
  • ortho-toluenesulfochloride
  • Benzenesulfonyl chloride, 2-methyl-
  • o-Toluenesulfonyl Chloride (contains ca. 23% isomer)&gt
  • O-TOLUENESULFONYL CHLORIDE ISO 9001：2015 REACH
  • Paroxetine Impurity 30
  • <i>o</i>-Toluenesulfonyl chloride
  • 2-Toluenesulfonyl chloride(contains ca.23% isomer)
  • 133-59-5
  • C7H7ClSO2
  • SULFONYL CHLORIDE
  • Organic Building Blocks
  • Sulfonyl Halides
  • Sulfur Compounds
  • Building Blocks
  • Organic Building Blocks
  • Sulfonyl Halides
  • Sulfur Compounds
  • Intermediates of Dyes and Pigments