2-Chloro-3-Methyl-4-pyridinecarboxylic Acid
- Product Name
- 2-Chloro-3-Methyl-4-pyridinecarboxylic Acid
- CAS No.
- 133928-73-1
- Chemical Name
- 2-Chloro-3-Methyl-4-pyridinecarboxylic Acid
- Synonyms
- 3-Methyl-2-chloroisonicotinic acid;3-Methyl-2-chloro-4-pyridinecarboxylic acid;2-chloro-3-Methylpyridine-4-carboxylic acid;2-Chloro-3-Methyl-4-pyridinecarboxylic Acid;3-Methyl-2-chloropyridine-4-carboxylic acid;4-Pyridinecarboxylic acid, 2-chloro-3-methyl-
- CBNumber
- CB02603777
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 133928-73-1.mol
2-Chloro-3-Methyl-4-pyridinecarboxylic Acid Property
- Boiling point:
- 412.7±40.0 °C(Predicted)
- Density
- 1.390±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 2.42±0.25(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H6ClNO2/c1-4-5(7(10)11)2-3-9-6(4)8/h2-3H,1H3,(H,10,11)
- InChIKey
- JYVLCHBMNCMRBO-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(C(O)=O)=C1C
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C368695
- Product name
- 2-Chloro-3-methylisonicotinicAcid
- Packaging
- 2.5g
- Price
- $505
- Updated
- 2021/12/16
- Product number
- 6142AA
- Product name
- 2-Chloro-3-methylisonicotinicacid
- Packaging
- 5g
- Price
- $1330
- Updated
- 2021/12/16
- Product number
- CS-0040466
- Product name
- 2-Chloro-3-methylisonicotinicacid
- Packaging
- 100mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- CS-0040466
- Product name
- 2-Chloro-3-methylisonicotinicacid
- Packaging
- 250mg
- Price
- $152
- Updated
- 2021/12/16
- Product number
- 6142AA
- Product name
- 2-Chloro-3-methylisonicotinicacid
- Packaging
- 250mg
- Price
- $159
- Updated
- 2021/12/16
2-Chloro-3-Methyl-4-pyridinecarboxylic Acid Chemical Properties,Usage,Production
Uses
2-Chloro-3-methylisonicotinic Acid is a derivative of Isonicotinic Acid (I821760) and is used as a reagent in the synthesis of N-pyridinylmethyl benzamide derivatives as anticancer agents.
Synthesis
133928-64-0
133928-73-1
Step 3: Synthesis of 2-chloro-3-methylpyridine-4-carboxylic acid A mixture of 2-chloro-N,3-dimethyl-N-phenylpyridine-4-carboxamide (2.2 g, 8.5 mmol) was mixed with a mixture of concentrated H2SO4 (23.2 mL) and water (16.8 mL), which was subsequently heated to 130 °C and kept for 46 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and poured into ice (200 mL) and stirred until the ice was completely melted. The mixture was adjusted to alkaline (pH 8) by batchwise addition of solid Na2CO3 (50.3 g). The suspension was filtered and the filtrate was acidified to pH 3 by the addition of 6 M HCl (aq) (ca. 1.5 mL).The resulting solid was collected by filtration, washed with water (20 mL) and dried under vacuum at 40 °C for 10 h to afford 2-chloro-3-methyl-4-pyridinecarboxylic acid (779 mg, 54%) as a pink solid.LC-MS purity 100%, m/z = 171.9, 173.9; 1H NMR (500 MHz, MeOD) δ ppm 8.30 (d, J = 4.89 Hz, 1H), 7.64 (d, J = 5.04 Hz, 1H), 2.58 (s, 3H).
References
[1] Tetrahedron, 1991, vol. 47, # 9, p. 1697 - 1706
[2] Patent: WO2012/142513, 2012, A1. Location in patent: Page/Page column 427-428
2-Chloro-3-Methyl-4-pyridinecarboxylic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-3-Methyl-4-pyridinecarboxylic Acid manufacturers
- Product
- 2-Chloro-3-methylisonicotinic acid 133928-73-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.4%
- Supply Ability
- 100 tons
- Release date
- 2022-01-25
- Product
- 2-Chloro-3-Methyl-4-pyridinecarboxylic Acid 133928-73-1
- Price
- US $220.00/G
- Min. Order
- 1G
- Purity
- 99%
- Supply Ability
- customise
- Release date
- 2018-08-01