3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

ChemicalBook > CAS DataBase List > 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

Product Name: 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide
CAS No.: 1009298-59-2
Chemical Name: 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide
Synonyms: CS-486;AZD2014;AZD2014, >=98%;AZD 2014; AZD-2014;AZD2014(Vistusertib);Vistusertib (AZD2014);Osimertinib Impurity 4;AZD2014;AZD 2014; AZD-2014;Vistusertib, 98%, a novel mTOR inhibitor;3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide
CBNumber: CB02604239
Molecular Formula: C25H30N6O3
Formula Weight: 462.54
MOL File: 1009298-59-2.mol

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3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Property

Melting point:: 233-237oC
Density: 1.231
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 14.45±0.46(Predicted)
form: Solid
color: Light Yellow

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17378
Product name: AZD 2014
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17378
Product name: AZD 2014
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 17378
Product name: AZD 2014
Purity: ≥98%
Packaging: 10mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 17378
Product name: AZD 2014
Purity: ≥98%
Packaging: 25mg
Price: $305
Updated: 2024/03/01

TRC

Product number: A808115
Product name: AZD2014
Packaging: 200mg
Price: $890
Updated: 2021/12/16

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3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Chemical Properties,Usage,Production

Uses

AZD2014 is a dual mTORC1 and mTORC2 inhibitor. Studies show that AZD2014 induces growth inhibition and cell death in breast cancer cell lines, including ER+ cell lines.

Biological Activity

azd2014 is a novel, potent and highly selective dual inhibitor of the mammalian rapamycin (mtorc1 and mtorc2) with an ic50 value of 2.8 nm. it is an oral inhibitor and possesses potential antineoplastic activity.azd2014 enhanced susceptibility of glioblastoma stem-like cells (gscs) to irradiation both in vitro and under orthotopic in vivo conditions. kahn j et al pretreated cd133+ and cd15+ gsc cells with azd2014 (2 μm) for 1 hour, followed by irradiation. the effect was then measured by clonogenic survival analysis [2]. using in vitro screening, they demonstrated that the combination of ibrutinib, an inhibitor of the tyrosine kinase btk, and azd2014 could dramatically induce apoptosis in abc-subtype dlbcl cell lines. thereby, the combination of azd2014 with a btk inhibitor is a promising therapeutic method to cure patients with abc-type dlbcl [3]. in hepatocellular carcinoma cells, azd2014 gave rise to a more complete inhibition of mtorc1 than rapamycin, while the inhibition of mtorc2 prevented the feedback activation of akt signaling. therefore, azd2014 was identified to be more efficacious in the induction of apoptosis, autophagy, and cell cycle arrest, resulting in a significant proliferation suppression of the cells, in contrast with rapamycin [4].in a recent human pharmacokinetic and pharmacodynamic study, a dose of 50mg bd(twice a day)azd2014 was recommended to achieve pharmacologically relevant plasma concentrations [5].

target

mTOR

References

optimization of potent and selective dual mtorc1 and mtorc2 inhibitors: the discovery of azd8055 and azd2014. bioorg med chem lett. 2013 mar 1;23(5):1212-6. the mtorc1/mtorc2 inhibitor azd2014 enhances the radiosensitivity of glioblastoma stem-like cells. neuro oncol. 2014 jan;16(1):29-37. synergistic induction of apoptosis by combination of btk and dual mtorc1/2 inhibitors in diffuse large b cell lymphoma. oncotarget. 2014 jul 15;5(13):4990-5001.dramatic antitumor effects of the dual mtorc1 and mtorc2 inhibitor azd2014 in hepatocellular carcinoma. am j cancer res. 2014 dec 15;5(1):125-39. ecollection 2015.first-in-human pharmacokinetic and pharmacodynamic study of the dual m-torc 1/2 inhibitor, azd2014. clin cancer res. 2015 mar 24. pii: clincanres.2422.2014.

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide manufacturers

Career Henan Chemical Co

Product: 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide 1009298-59-2
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1009298-59-2, 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamideRelated Search:

Everolimus INK 128 (MLN0128) BKM120 (NVP-BKM120, Buparlisib) AZD-8055 MK-2206 2HCl Pictilisib AZD-9291 Oxacillin Sodium Impurity D(EP) Oxacillin Sodium Impurity I(EP) Osimertinib Impurity M Osimertinib Impurity N Oxacillin Sodium Impurity G(EP) 1,4-Benzenediamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-2-nitro- AZ-5104 AZ 7550 1,2,4-Benzenetriamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]- 2-Propenamide, N-[2-[[2-(dimethyloxidoamino)ethyl]methyloxidoamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]- 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

AZD2014

3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide AZD2014

AZD2014 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide

3-{2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl}-N-methylbenzamide

AZD2014, >=98%

AZD2014(Vistusertib)

AZD2014;AZD 2014; AZD-2014

Vistusertib, 98%, a novel mTOR inhibitor

Vistusertib (AZD2014)

CS-486

AZD 2014; AZD-2014

Osimertinib Impurity 4

Benzamide, 3-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-N-methyl-

3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide USP/EP/BP

inhibit,Vistusertib,Apoptosis,Mammalian target of Rapamycin,AZD 2014,mTOR,Autophagy,Inhibitor,AZD-2014

1009298-59-2

Inhibitors

Akt

mTOR

PI3K

PI3K/Akt/mTOR