1H-pyrazolo[4,3-b]pyridine-5-carbonitrile

Product Name: 1H-pyrazolo[4,3-b]pyridine-5-carbonitrile
CAS No.: 1033772-22-3
Chemical Name: 1H-pyrazolo[4,3-b]pyridine-5-carbonitrile
Synonyms: 1H-pyrazolo[4,3-b]pyridine-5-carbonitrile
CBNumber: CB02604769
Molecular Formula: C7H4N4
Formula Weight: 144.13
MOL File: 1033772-22-3.mol

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1H-pyrazolo[4,3-b]pyridine-5-carbonitrile Property

Boiling point:: 397.1±22.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 9.13±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: Z3824
Product name: 1H-Pyrazolo[4,3-b]pyridine-5-carbonitrile
Packaging: 250mg
Price: $116
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0387132
Product name: 1H-PYRAZOLO[4,3-B]PYRIDINE-5-CARBONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $497.08
Updated: 2021/12/16

Matrix Scientific

Product number: 126634
Product name: 1H-Pyrazolo[4,3-b]pyridine-5-carbonitrile
Purity: >95%
Packaging: 1g
Price: $1764
Updated: 2021/12/16

AK Scientific

Product number: Z3824
Product name: 1H-Pyrazolo[4,3-b]pyridine-5-carbonitrile
Packaging: 1g
Price: $247
Updated: 2021/12/16

Crysdot

Product number: CD11362319
Product name: 1H-Pyrazolo[4,3-b]pyridine-5-carbonitrile
Purity: 98%
Packaging: 1g
Price: $250
Updated: 2021/12/16

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1H-pyrazolo[4,3-b]pyridine-5-carbonitrile Chemical Properties,Usage,Production

Synthesis

7677-24-9

1033772-21-2

1033772-22-3

General procedure for the synthesis of 1H-pyrazolo[4,3-b]pyridine-5-carbonitrile from trimethylcyanosilane (TMSCN) and 4-hydroxy-1-[[2-(trimethylmethylsilyl)ethoxy]methyl]-1H-pyrazolo[4,3-b]pyridinium (CAS: 1033772-21-2, 1.59 g, 6 mmol): TMSCN ( 1.13 mL, 9 mmol) was added to a solution of 4-hydroxy-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrazolo[4,3-b]pyridinium in dichloromethane (DCM, 130 mL). The reaction mixture was stirred at room temperature for 5 minutes before N,N-dimethylcarbamoyl chloride ((Me)2N(C(O)Cl, 0.83 mL, 9 mmol) was added. The reaction mixture was continued to be stirred at room temperature for 4 days. Upon completion of the reaction, the reaction mixture was diluted with DCM and subsequently washed with brine to concentrate the organic phase. Finally, the target product 1H-pyrazolo[4,3-b]pyridine-5-carbonitrile (1 g, 61% yield) was purified by column chromatography.

References

[1] Patent: WO2008/71451, 2008, A1. Location in patent: Page/Page column 52-53

1H-pyrazolo[4,3-b]pyridine-5-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-pyrazolo[4,3-b]pyridine-5-carbonitrile Suppliers

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