4-Oxazolecarboxylicacid, 2-broMo-
Application- Product Name
- 4-Oxazolecarboxylicacid, 2-broMo-
- CAS No.
- 1167055-73-3
- Chemical Name
- 4-Oxazolecarboxylicacid, 2-broMo-
- Synonyms
- 2-bromo-4-Oxazolecarboxylic acid;2-BroMooxazole-4-carboxylic acid;4-Oxazolecarboxylicacid, 2-broMo-;2-bromo-1,3-oxazole-4-carboxylic acid
- CBNumber
- CB02609931
- Molecular Formula
- C4H2BrNO3
- Formula Weight
- 191.97
- MOL File
- 1167055-73-3.mol
4-Oxazolecarboxylicacid, 2-broMo- Property
- Boiling point:
- 363.0±34.0 °C(Predicted)
- Density
- 2.038±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.00±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B111460
- Product name
- 2-Bromooxazole-4-carboxylicAcid
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- HCH0363375
- Product name
- 2-BROMOOXAZOLE-4-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.47
- Updated
- 2021/12/16
- Product number
- Z3924
- Product name
- 2-Bromooxazole-4-carboxylicacid
- Packaging
- 5g
- Price
- $774
- Updated
- 2021/12/16
- Product number
- Z3924
- Product name
- 2-Bromooxazole-4-carboxylicacid
- Packaging
- 10g
- Price
- $1461
- Updated
- 2021/12/16
- Product number
- CD11342822
- Product name
- 2-Bromooxazole-4-carboxylicacid
- Purity
- 95%
- Packaging
- 25g
- Price
- $1867
- Updated
- 2021/12/16
4-Oxazolecarboxylicacid, 2-broMo- Chemical Properties,Usage,Production
Application
2-Bromooxazole-4-carboxylic acid can be used as a pharmaceutical synthesis intermediate. It is prepared by reacting ethyl 2-bromooxazole-4-carboxylate with lithium hydroxide. 2-Bromooxazole-4-carboxylic acid can also be used to prepare IRAK inhibitors.
Synthesis
460081-20-3
1167055-73-3
General procedure for the synthesis of 2-bromooxazole-4-carboxylic acid from ethyl 2-bromooxazole-4-carboxylate: ethyl 2-bromo-1,3-oxazole-4-carboxylate (2.5 g, 11.36 mmol) was dissolved in a mixed solvent of THF and methanol (9:1, v/v/v), and 1 M aqueous lithium hydroxide (22.73 mL, 22.73 mmol) was slowly added. The reaction mixture was stirred at room temperature for 1 h. The reaction mixture was diluted with water and the pH was adjusted with dilute hydrochloric acid to 2. The precipitate was filtered and dried to give 2-bromoxazole-4-carboxylic acid (1.1 g). The filtrate was extracted three times with ethyl acetate, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-bromoxazole-4-carboxylic acid (0.85 g). The total yield was 88%. Mass spectrometry analysis showed m/z [M+H]+ of 192.0.
References
[1] Patent: WO2011/51540, 2011, A1. Location in patent: Page/Page column 152
4-Oxazolecarboxylicacid, 2-broMo- Preparation Products And Raw materials
Raw materials
Preparation Products
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