ChemicalBook > CAS DataBase List > (Difluoromethyl)trimethylsilane

(Difluoromethyl)trimethylsilane

Product Name
(Difluoromethyl)trimethylsilane
CAS No.
65864-64-4
Chemical Name
(Difluoromethyl)trimethylsilane
Synonyms
Difluormethyltrimethylsilan;(DifluoroMethyl)triMethylsilane;TriMethyl(difluoroMethyl)silane;Silane, (difluoroMethyl)triMethyl-;(Difluoromethyl)trimethylsilane>(Difluoromethyl)trimethylsilane,97%;(Difluoromethyl)trimethylsilane >=98.0% (GC)
CBNumber
CB02610597
Molecular Formula
C4H10F2Si
Formula Weight
124.2
MOL File
65864-64-4.mol
More
Less

(Difluoromethyl)trimethylsilane Property

Boiling point:
52°C(lit.)
Density 
0.877±0.06 g/cm3(Predicted)
refractive index 
1.3560-1.3600
Flash point:
-17℃
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
form 
clear liquid
color 
Colorless to Almost colorless
Specific Gravity
0.91
Hydrolytic Sensitivity
4: no reaction with water under neutral conditions
BRN 
2423974
InChIKey
OOKFLLNDYNWCHK-UHFFFAOYSA-N
CAS DataBase Reference
65864-64-4
More
Less

Safety

Hazard Codes 
F
Risk Statements 
11
Safety Statements 
15-7-35
RIDADR 
UN 1993BF 3 / PGII
WGK Germany 
3
HazardClass 
3
PackingGroup 
II
HS Code 
29319090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
744050
Product name
(Difluoromethyl)trimethylsilane
Purity
≥98.0% (GC)
Packaging
1ml
Price
$264
Updated
2024/03/01
Sigma-Aldrich
Product number
744050
Product name
(Difluoromethyl)trimethylsilane
Purity
≥98.0% (GC)
Packaging
5ml
Price
$756
Updated
2024/03/01
TCI Chemical
Product number
D4364
Product name
(Difluoromethyl)trimethylsilane
Purity
>97.0%(GC)
Packaging
1mL
Price
$54
Updated
2024/03/01
TCI Chemical
Product number
D4364
Product name
(Difluoromethyl)trimethylsilane
Purity
>97.0%(GC)
Packaging
5mL
Price
$176
Updated
2024/03/01
TCI Chemical
Product number
D4364
Product name
(Difluoromethyl)trimethylsilane
Purity
>97.0%(GC)
Packaging
25mL
Price
$503
Updated
2023/01/07
More
Less

(Difluoromethyl)trimethylsilane Chemical Properties,Usage,Production

Description

A direct nucleophilic difluoromethylation reagent. The nucleophilic activation of the silicon center with Lewis base initiators allows transfer of the difluoromethyl moiety to electrophiles such as aldehydes, ketones, and aldimines. The copper-mediated difluoromethylation of halides using TMSCF2H tolerates amine, ether, amide, ester, aromatic bromide, and protected alcohol functionalities in aryl iodides and occurs in high yield and stereoselectivity with vinyl iodides.

Uses

(Difluoromethyl)trimethylsilane, can be used for difluoromethylation of carbonyl compounds. Difluromethylated compounds are very useful in materials science and medicinal and agricultural chemistry.

Reactions

(1) Direct bromination to prepare TMSCF2Br.

(2) Difluoromethylation of aldehydes and ketones.

(3) Difluoromethylation of aldimines.

(4) Difluoromethylation of aryl and vinyl iodides.

References

[1] MIKHAIL D. KOSOBOKOV. Difluoro(trimethylsilyl)acetonitrile: Synthesis and Fluoroalkylation Reactions[J]. The Journal of Organic Chemistry, 2012, 77 13: 5850-5855. DOI:10.1021/jo301094b.
[2] YANCHUAN ZHAO. Efficient and Direct Nucleophilic Difluoromethylation of Carbonyl Compounds and Imines with Me3SiCF2H at Ambient or Low Temperature[J]. Organic Letters, 2011, 13 19: 5342-5345. DOI:10.1021/ol202208b.
[3] PATRICK S. FIER  John F H. Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides[J]. Journal of the American Chemical Society, 2012, 134 12: 5524-5527. DOI:10.1021/ja301013h.

(Difluoromethyl)trimethylsilane Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(Difluoromethyl)trimethylsilane Suppliers

Americas 1 China 121 Europe 1 India 2 Japan 1 Russia 1 Switzerland 1 United Kingdom 2 United States 10 Global 140
Nanjing ShengSai Chemical Co., Ltd.
Tel
025-85205967 13951876367
Fax
025-85205967
Email
shengsaichem@163.com
Country
China
ProdList
811
Advantage
58
Tianjin Keluo Pharmaceutical Technology Co. LTD
Tel
022-23869539 18920052327
Fax
022-83711180
Email
281258989@qq.com
Country
China
ProdList
62
Advantage
58
Yangzhou modier Electronic Materials Co., Ltd
Tel
0514-82098883; 13761402923
Email
market@modeltemol.com
Country
China
ProdList
923
Advantage
58
Shandong Dongyue Polymer Material Co.,Ltd
Tel
13475593937
Email
1206350038@qq.com
Country
China
ProdList
6
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9510
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19186
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
6791
Advantage
65
Shanghai Youd Chemical Technology Co., Ltd.
Tel
021-37910092; 15821801668
Fax
021-37910267
Email
cong44@126.com
Country
China
ProdList
300
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9478
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq：2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9347
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
SHANG FLUORO
Tel
021-65170832 15601903708
Email
qinba_1@163.com
Country
China
ProdList
374
Advantage
60
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11663
Advantage
59
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5793
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
3967
Advantage
60
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12036
Advantage
58
Hangzhou Copiore Chemical Co., Ltd.
Tel
0571-56076030 13757145729
Fax
0571-56076030
Email
sales@copiore.com
Country
China
ProdList
278
Advantage
58
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
021-58088081 Q3252066219
Fax
QQ3382968513
Email
danping@shsendpharm.com
Country
China
ProdList
3100
Advantage
55
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9951
Advantage
56
skychemical Co.Ltd
Tel
021-20960837,QQ1332204249
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
3332
Advantage
55
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
10215
Advantage
58
Greenherbs Science and Technology Development Co., Ltd.
Tel
010-61136123
Fax
+86 (10) 8857-9127
Email
pub02@greenherbs.com.cn
Country
China
ProdList
4049
Advantage
58
JinJin Le Chemical Co., Ltd
Tel
10106090
Email
jjlchem2@163.com
Country
China
ProdList
9981
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
Advantage
60
LinkChem Co.,Ltd.
Tel
021-021-58950110 13124863828
Fax
021-20922272
Email
sales@linkchem.cn
Country
China
ProdList
2998
Advantage
58
Jiaxing Deyi Chemical Co., Ltd.
Tel
0573-86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8023
Advantage
58
Wuxi AppTec
Tel
022-59987777 13552403979
Email
jia_guoqiang@wuxiapptec.com
Country
China
ProdList
22345
Advantage
58
Hubei XinMingTai Chemical Co., Ltd.
Tel
177-7179-1433 17771741533
Fax
027-62437337
Email
1228159977@qq.com
Country
China
ProdList
1298
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718 +86-13336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29793
Advantage
60
Aikon International Limited
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15818
Advantage
58
Shanghai QiQiao Biological Technology Co., Ltd.
Tel
021-37653318; 15221675714
Email
515366396@qq.com
Country
China
ProdList
2089
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25004
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
10789
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Shanghai zhigan biotechnology co., LTD
Tel
Email
zhiqianbio@126.com
Country
China
ProdList
19778
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
10279
Advantage
58
Shanghai Jinghui Industrial Co., Ltd.
Tel
021-6125035 18019281355
Email
vlchemjh@126.com
Country
China
ProdList
295
Advantage
58
More
Less

View Lastest Price from (Difluoromethyl)trimethylsilane manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
(Difluoromethyl)trimethylsilane 65864-64-4
Price
US $0.10/kg
Min. Order
0.004999999888241291kg
Purity
99.99%
Supply Ability
20 tons
Release date
2024-04-15
Henan Aochuang Chemical Co.,Ltd.
Product
(Difluoromethyl)trimethylsilane 65864-64-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29
Zhuozhou Wenxi import and Export Co., Ltd
Product
(Difluoromethyl)trimethylsilane 65864-64-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

65864-64-4, (Difluoromethyl)trimethylsilaneRelated Search:

Triethylsilane 2-(Trimethylsilyl)ethoxymethyl chloride 1H,1H,2H,2H-Perfluorooctyltriethoxysilane

  • (Difluoromethyl)trimethylsilane >=98.0% (GC)
  • Silane, (difluoroMethyl)triMethyl-
  • TriMethyl(difluoroMethyl)silane
  • Difluormethyltrimethylsilan
  • (DifluoroMethyl)triMethylsilane
  • (Difluoromethyl)trimethylsilane&gt
  • (Difluoromethyl)trimethylsilane,97%
  • 65864-64-4
  • C4H10F2Si