2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid
- Product Name
- 2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid
- CAS No.
- 739364-95-5
- Chemical Name
- 2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid
- Synonyms
- 2-Methylpyrazolo[1;Anagliptin InterMediate A;2-Methylpyrazolo[1,5-a]py...;5-a]pyriMidine-6-carboxylic acid;2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid;2-Methylpyraolo[1,5- a]pyriMidine-6-carboxylic acid;Pyrazolo[1,5-a]pyrimidine-6-carboxylic acid, 2-methyl-;2-Methyl pyrazolo [1,5- α] Pyrimidine-6-carboxylic acid;2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 95+%;2-Methylpyrazolo[1,5-A]pyrimidine-6-carboxylic acid(PPCA)
- CBNumber
- CB02615178
- Molecular Formula
- C8H7N3O2
- Formula Weight
- 177.16
- MOL File
- 739364-95-5.mol
2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid Property
- Melting point:
- 238 °C(dec.)
- Density
- 1.49±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- -0.17±0.41(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C8H7N3O2/c1-5-2-7-9-3-6(8(12)13)4-11(7)10-5/h2-4H,1H3,(H,12,13)
- InChIKey
- YHVGUXFUOSJCFJ-UHFFFAOYSA-N
- SMILES
- C12=CC(C)=NN1C=C(C(O)=O)C=N2
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M2760
- Product name
- 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $125
- Updated
- 2025/07/31
- Product number
- M2760
- Product name
- 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $470
- Updated
- 2023/01/07
- Product number
- M327160
- Product name
- 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid
- Packaging
- 5g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- CS-W003908
- Product name
- 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid
- Purity
- ≥98.0%
- Packaging
- 10g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 4H58-1-L6
- Product name
- 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid Chemical Properties,Usage,Production
Uses
2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic Acid is a reactant used in the preparation of DPP-IV inhibitors.
Synthesis
338953-49-4
739364-95-5
The general procedure for the synthesis of 2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid, using the compound (CAS: 338953-49-4) as a starting material, was as follows (Intermediate Example 16): 2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid amide (475 mg) was dissolved in ethanol (5 mL), and a 5 N sodium hydroxide solution was subsequently added to the solution (2 mL). The reaction mixture was stirred at 70 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, an appropriate amount of water was added and the reaction mixture was washed with ethyl acetate. After separating the aqueous phase, 2 N hydrochloric acid was added dropwise until the pH became acidic. The precipitated white crystals were collected by filtration and washed sequentially with water and hexane. Finally, the resulting crystals were dried under reduced pressure to afford the target product 2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (300 mg, yield: 63%). Product mass spectral data: ESI/MS m/z 178 ([M+H]+), 176 ([M-H]-).
References
[1] Patent: EP1595866, 2005, A1. Location in patent: Page/Page column 13
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 23, p. 7221 - 7227
2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid manufacturers
- Product
- 2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid 739364-95-5
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1000KGS
- Release date
- 2021-11-08
- Product
- 2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid 739364-95-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-19
- Product
- 2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid 739364-95-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-21