3-b]pyridine

Product Name: 3-b]pyridine
CAS No.: 1357945-27-7
Chemical Name: 3-b]pyridine
Synonyms: o[4,3-b]pyridine;oro-3-iodo-1H-pyrazoL;5-chloro-3-iodo-1H-pyrazolo[4;5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine;1H-Pyrazolo[4,3-b]pyridine, 5-chloro-3-iodo-
CBNumber: CB02616504
Molecular Formula: C6H3ClIN3
Formula Weight: 279.47
MOL File: 1357945-27-7.mol

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3-b]pyridine Property

Boiling point:: 404.9±40.0 °C(Predicted)
Density: 2.284±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 7.79±0.40(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C366890
Product name: 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine
Packaging: 5g
Price: $1100
Updated: 2021/12/16

Matrix Scientific

Product number: 189033
Product name: 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine
Packaging: 5g
Price: $2296
Updated: 2021/12/16

Matrix Scientific

Product number: 189033
Product name: 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine
Packaging: 500mg
Price: $526
Updated: 2021/12/16

Matrix Scientific

Product number: 189033
Product name: 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine
Packaging: 1g
Price: $766
Updated: 2021/12/16

Crysdot

Product number: CD11279631
Product name: 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine
Purity: 95+%
Packaging: 5g
Price: $776
Updated: 2021/12/16

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3-b]pyridine Chemical Properties,Usage,Production

Uses

5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine is a reactant used for the synthesis of Benzothiazol-6-ylacetic acid derivatives as anti-HIV.

Synthesis

94220-45-8

1357945-27-7

To a solution of 5-chloro-1H-pyrazolo[4,3-b]pyridine (XIII) (13 g, 84.7 mmol) in N,N-dimethylformamide (DMF) (100 mL) was added iodine (43.0 g, 169 mmol), followed by batchwise addition of potassium hydroxide powder (23.75 g, 423 mmol), and the reaction mixture was cooled in an ice water bath. The reaction mixture was stirred at 25 °C overnight. The solid potassium hydroxide was removed by filtration and the filter cake was washed with ethyl acetate (EtOAc). Most of the DMF was evaporated under reduced pressure and the residue was diluted with water (200 mL) and extracted with ethyl acetate (5 × 200 mL). The organic phases were combined, washed with saturated saline (500 mL) and dried over anhydrous sodium sulfate (Na2SO4). The organic phases were concentrated to afford 5-chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine (XIV) as an orange solid (23.5 g, 84.1 mmol, 99.3% yield). The m/z of C6H3ClIN3 was measured to be 279.9 ([M+H]+) by electrospray ionization mass spectrometry (ESIMS).

References

[1] Patent: WO2017/23989, 2017, A1. Location in patent: Paragraph 0606; 0607
[2] Patent: WO2017/23972, 2017, A1. Location in patent: Paragraph 0606; 0607
[3] Patent: WO2017/24015, 2017, A1. Location in patent: Paragraph 006
[4] Patent: WO2017/23988, 2017, A1. Location in patent: Paragraph 0607
[5] Patent: WO2017/220431, 2017, A1. Location in patent: Page/Page column 36; 37

3-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-b]pyridine Suppliers

China 51 India 2 United States 5 Global 58

Hunan Hui Bai Shi Biotechnology Co., Ltd.

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Wuhan ariel chemical Co., LTD.

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Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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Chengdu Focus Pharmaceutical Technology Co., Ltd.

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Aikon International Limited

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Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
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View Lastest Price from 3-b]pyridine manufacturers

Career Henan Chemical Co

Product: 3-b]pyridine 1357945-27-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

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1357945-27-7