2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride
- Product Name
- 2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride
- CAS No.
- 112282-24-3
- Chemical Name
- 2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride
- Synonyms
- BRL-52537;BRL52537;BRL 52537 hydrochloride, kappa-opioid agonist;2-(3,4-DICHLOROPHENYL)-1-(2-(PYRROLIDIN-1-YLMETHYL)PIPERIDIN-1-YL)ETHANONE HCL;2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride
- CBNumber
- CB02616786
- Molecular Formula
- C18H25Cl3N2O
- Formula Weight
- 391.7629
- MOL File
- 112282-24-3.mol
2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride Property
- Melting point:
- 246-248 °C(Solv: methanol (67-56-1))
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- insoluble in H2O
- form
- solid
- color
- White
- Water Solubility
- Soluble to 5 mM in water with gentle warming
N-Bromosuccinimide Price
- Product number
- B677740
- Product name
- BRL52537Hydrochloride
- Packaging
- 100mg
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- B6407
- Product name
- BRL52537hydrochloride
- Packaging
- 50mg
- Price
- $843
- Updated
- 2021/12/16
- Product number
- DC7891
- Product name
- BRL52537HYDROCHLORIDE
- Purity
- >98%
- Packaging
- 100mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- 112282243
- Product name
- 2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylmethyl)piperidin-1-yl)ethanonehydrochloride
- Packaging
- 1g
- Price
- $943.34
- Updated
- 2021/12/16
- Product number
- A300626
- Product name
- BRL52537hydrochloride
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $28
- Updated
- 2021/12/16
2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride Chemical Properties,Usage,Production
Uses
BRL 52537 is the most selective κ/μ and one of the most potent known κ ligands. Shown to attenuate ischemia-evoked nitric oxide production. Analgesic agent.
Biological Activity
brl 52537 hydrochloride is a potent and selective agonist of κ/μ-opioid receptor with ki value of 0.24 nm for κ-opioid receptor [1].the κ-opioid receptor (kor) is a type of opioid receptor for opioid peptide dynorphin and controls addiction. also, kor plays an important role in stress, anxiety, anhedonia, depression and increased drug-seeking behavior.brl 52537 hydrochloride is a potent and selective κ/μ-opioid receptor agonist. in the mouse tail flick model, brl 52537 showed antinociception with ed50 value of 0.05 mg/kg, which was 25 times more potent than morphine [1]. in wt male mice with middle cerebral artery occlusion, brl 52537 significantly decreased infarct volumes at 72 h of reperfusion. however, brl 52537 had no effect in neuronal no synthase null mutants (nnos-/-) mice or in the wt female mice. these results suggested that brl 52537 exhibited neuroprotection through inhibition of ischemia-evoked no production and nnos activity [2]. in adult rat dorsal root ganglia (drgs), brl 52537 inhibited tetrodotoxin-resistant (ttx-r) sodium currents in an opioid receptor-independent way, which also contributed to the antinociceptive effects [3]. in rats with cerebral ischemia/reperfusion (i/r) injury, brl52537 inhibited neuronal apoptosis and brain damage. also, brl52537 increased the level of phosphorylated stat3 and reduced caspase-3 expression [4].
storage
Store at RT
References
[1]. vecchietti v, giordani a, giardina g, et al. (2s)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics. j med chem, 1991, 34(1): 397-403.
[2]. zeynalov e, nemoto m, hurn pd, et al. neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide. j cereb blood flow metab, 2006, 26(3): 414-420.
[3]. su x, castle na, antonio b, et al. the effect of kappa-opioid receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons. anesth analg, 2009, 109(2): 632-640.
[4]. fang s, xu h, lu j, et al. neuroprotection by the kappa-opioid receptor agonist, brl52537, is mediated via up-regulating phosphorylated signal transducer and activator of transcription-3 in cerebral ischemia/reperfusion injury in rats. neurochem res, 2013, 38(11): 2305-2312.
2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-(3,4-Dichlorophenyl)-1-(2-(pyrrolidin-1-ylMethyl)piperidin-1-yl)ethanone hydrochloride Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 8011
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- 021-38015121 18438616290
- lanwu@univ-bio.com
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58