2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide
- Product Name
- 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide
- CAS No.
- 280773-17-3
- Chemical Name
- 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide
- Synonyms
- N-(5-chloro-pyridin-2-yl)-5-Methoxy-2-aMinobenzaMide;N-(5-chloropyridin-2-yl)-2-yl)-5-methoxy-2-aminobenzamide;-5-methoxybenzamide;Betrixaban Impurity 4;Betrixaban 2-Amino Impurity;2-Amino-N-(5-chloropyridin-2-yl);2-Amino-N-(5-chloro-2-pyridyl)-5-methoxybenzamide;2-AMino-N-(5-chloro-2-pyridinyl)-5-MethoxybenzaMide;2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide;Benzamide, 2-amino-N-(5-chloro-2-pyridinyl)-5-methoxy-
- CBNumber
- CB02616913
- Molecular Formula
- C13H12ClN3O2
- Formula Weight
- 277.71
- MOL File
- 280773-17-3.mol
2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide Property
- Boiling point:
- 396.9±42.0 °C(Predicted)
- Density
- 1.390
- storage temp.
- 2-8°C(protect from light)
- pka
- 11.19±0.70(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C13H12ClN3O2/c1-19-9-3-4-11(15)10(6-9)13(18)17-12-5-2-8(14)7-16-12/h2-7H,15H2,1H3,(H,16,17,18)
- InChIKey
- GCCIHZVIPXGAPR-UHFFFAOYSA-N
- SMILES
- C(NC1=NC=C(Cl)C=C1)(=O)C1=CC(OC)=CC=C1N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H371May cause damage to organs
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- W5102
- Product name
- 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide
- Packaging
- 10g
- Price
- $149
- Updated
- 2021/12/16
- Product number
- HCH0363033
- Product name
- 2-AMINO-N-(5-CHLOROPYRIDIN-2-YL)-5-METHOXYBENZAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.94
- Updated
- 2021/12/16
- Product number
- W5102
- Product name
- 2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide
- Packaging
- 100g
- Price
- $681
- Updated
- 2021/12/16
- Product number
- 280773173
- Product name
- N-(5-chloro-pyridin-2-yl)-5-methoxy-2-aminobenzamide
- Packaging
- 250mg
- Price
- $727.6
- Updated
- 2021/12/16
- Product number
- 280773173
- Product name
- N-(5-chloro-pyridin-2-yl)-5-methoxy-2-aminobenzamide
- Packaging
- 500mg
- Price
- $931
- Updated
- 2021/12/16
2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide Chemical Properties,Usage,Production
Synthesis
280773-16-2
280773-17-3
General procedure for the synthesis of N-(5-chloro-2-pyridinyl)-5-methoxy-2-nitrobenzamide from N-(5-chloro-2-pyridinyl)-5-methoxy-2-aminobenzamide: N-(5-chloro-2-pyridinyl)-5-methoxy-2-nitrobenzamide (30 g, 1.0 eq.) was suspended in methanol (300 ml, 10 v/v) and added with ferric chloride (1.58 g, 0.1 eq.) and heated to reflux. Subsequently, hydrazine hydrate (80%, 24.4 g, 4.0 eq.) was slowly added dropwise and the reaction was kept under reflux conditions for 6 hours. The reaction was monitored by HPLC until the peak area of the feedstock was less than 0.3%. After completion of the reaction, most of the solvent was removed by concentration under reduced pressure and cooled to room temperature. Ethyl acetate was added and stirred for 1 hour. The organic phase was washed sequentially with water and saturated brine, separated and dried over anhydrous sodium sulfate. Finally, concentrated to dryness under reduced pressure to obtain a light yellow solid product. The purity of the product was greater than 98% and the yield was 93%.
References
[1] Patent: CN108586325, 2018, A. Location in patent: Paragraph 0021; 0030-0036
[2] Patent: US2007/112039, 2007, A1. Location in patent: Page/Page column 10-11
[3] Patent: WO2008/57972, 2008, A1. Location in patent: Page/Page column 32-33; 45-46
[4] Patent: US2008/153876, 2008, A1. Location in patent: Page/Page column 24-25
[5] Patent: WO2011/84519, 2011, A1. Location in patent: Page/Page column 38-39
2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide manufacturers
- Product
- 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide 280773-17-3
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-07-26