ChemicalBook > CAS DataBase List > 7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide

7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide

Product Name
7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide
CAS No.
142557-61-7
Chemical Name
7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide
Synonyms
A 484954;A-484954(A 484954);A-484954, 10 mM in DMSO;eEF2K Inhibitor, A-484954;eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem;7-AMino-1-cyclopropyl-3-ethyl-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide;7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-6-carboxamide;7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamid;7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide;7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide
CBNumber
CB02621577
Molecular Formula
C13H15N5O3
Formula Weight
289.29
MOL File
142557-61-7.mol
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7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide Property

Boiling point:
522.9±60.0 °C(Predicted)
Density 
1.522±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
2-8°C
solubility 
DMSO: soluble3mg/mL, clear (warmed)
pka
14.26±0.20(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
324516
Product name
eEF2K Inhibitor, A-484954
Packaging
10mg
Price
$279
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0861
Product name
A-484954
Purity
≥98% (HPLC)
Packaging
5mg
Price
$121
Updated
2022/05/15
Cayman Chemical
Product number
28279
Product name
A-484954
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
28279
Product name
A-484954
Packaging
25mg
Price
$420
Updated
2024/03/01
Cayman Chemical
Product number
28279
Product name
A-484954
Packaging
1mg
Price
$32
Updated
2024/03/01
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7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide Chemical Properties,Usage,Production

Description

A-484954 is an ATP-competitive inhibitor of eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 420 nM). It reduces eEF-2K autophosphorylation in PC3, HeLa, H460, H1299, and MDA-MB-231 cancer cells when used at a concentration of 75 μM.

Uses

A-484954 has been used a selective and potent inhibitor to inhibit eEF2K (eukaryotic elongation factor 2 kinase), in order to check the enhancement of synaptic transmission in the stratum radiatum of the hippocampal CA1 region. It has also been used as an eEF2K inhibitor to monitor real-time luminescence of U2OS Arntl::dLUC cells.

Uses

7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide,a pyrido[2,3-d]pyrimidin-2,4(1H,3H)-dione derivative with potential use as herbicide antidote.

Biochem/physiol Actions

A-484954 is a potent, selective inhibitor of eukaryotic longation factor-2 kinase (eEF2K). Eukaryotic elongation factor-2, which is required for protein synthesis, is inactivated upon phosphorylation by eEF2K.

in vivo

A484954 causes relaxation in E (+) and E (-) aorta or mesenteric artery precontracted with NA. Pretreatment with L-NAME but not indomethacin or cimetidine partially inhibits the A484954-induced relaxation in mesenteric artery[2].
Long-term A-484954 treatment inhibits MCT-induced increases PA pressure. It is revealed that A-484954 inhibits MCT-induced PA hypertrophy and fibrosis but not impairment of endothelium-dependent and -independent relaxation. Furthermore, A-484954 inhibits MCT-induced NADPH oxidase-1 expression and ROS generation as well as matrix metalloproteinase-2 activation[3].

storage

Store at +4°C

References

[1] RAMAKRISHNA EDUPUGANTI . Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors[J]. Bioorganic & Medicinal Chemistry, 2014, 22 17: Pages 4910-4916. DOI: 10.1016/j.bmc.2014.06.050

7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide Suppliers

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View Lastest Price from 7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide manufacturers

Career Henan Chemical Co
Product
7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide 142557-61-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-18

142557-61-7, 7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMideRelated Search:


  • 7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide
  • 7-AMino-1-cyclopropyl-3-ethyl-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide
  • A-484954(A 484954)
  • A 484954
  • 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamideddd
  • eEF2K Inhibitor, A-484954
  • 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide
  • 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamid
  • eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem
  • 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-6-carboxamide
  • Pyrido[2,3-d]pyrimidine-6-carboxamide, 7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-
  • CaMK,Autophagy,Inhibitor,Calmodulin-dependent protein kinases,A-484954,A484954,inhibit,Calmodulin-dependent kinases
  • A-484954, 10 mM in DMSO
  • 142557-61-7
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