JDTic (2HCl)

Product Name: JDTic (2HCl)
CAS No.: 785835-79-2
Chemical Name: JDTic (2HCl)
Synonyms: CS-648;JDTic (2HCl);JDTic hydrochloride;JDTic (dihydrochloride);(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;(3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide;(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride;(3R)-7-hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride;(3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide hydrochloride
CBNumber: CB02624189
Molecular Formula: C28H40ClN3O3
Formula Weight: 502.1
MOL File: 785835-79-2.mol

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JDTic (2HCl) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0538
Product name: JDTicdihydrochloride
Purity: 99.79%
Packaging: 5mg
Price: $170
Updated: 2021/12/16

ChemScene

Product number: CS-0538
Product name: JDTicdihydrochloride
Purity: 99.79%
Packaging: 10mg
Price: $271
Updated: 2021/12/16

ChemScene

Product number: CS-0538
Product name: JDTicdihydrochloride
Purity: 99.79%
Packaging: 50mg
Price: $1046
Updated: 2021/12/16

DC Chemicals

Product number: DC9524
Product name: JDTic(dihydrochloride)
Purity: >98%
Packaging: 1g
Price: $3600
Updated: 2021/12/16

Crysdot

Product number: CD31000793
Product name: JDTicdihydrochloride
Purity: 98+%
Packaging: 5mg
Price: $320
Updated: 2021/12/16

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JDTic (2HCl) Chemical Properties,Usage,Production

Biological Activity

jdtic is a selective inhibitor of kappa opioid receptor with ic50 value of 0.02nm [1].jdtic is one of the kappa opioid receptor selective antagonists. these antagonists are thought as potential pharmacotherapies for addiction, anxiety disorders, depression, psychosis disorders and obesity. because of the unique structural feature of jdtic, it is more selective and potent for kor activity than other kor antagonists. jdtic is shown to block the antinociceptive response of nicotine in the tail-flick test with a dose-dependent manner. it (8 mg/kg) can also block the nicotine withdrawal signs in mice via effecting the expression of a cpa associated with nicotine withdrawal. additionally, jdtic is also reported to decrease the number of somatic withdrawal signs in morphine-dependent rats [2,3].

target

kappa opioid receptor

References

[1] michael p. hedrick, palak gosalia, kelin li, kevin frankowski, shenghua shi, thomas e. prisinzano, frank schoenen, jeffrey aubé, ying su, s. vasile, eduard sergienko, wilson gray, santosh hariharan, loribelle milan, susanne heynen-genel, bryan l. roth, jon evans, vincent setola, thomas d.y. chung, marc caron, laura m. bohn and lawrence s. barak. antagonist for the kappa opioid receptor. molecular libraries. 2011 jun: 1-32.
[2] scott p. runyon, lawrence e. brieaddy, s. wayne mascarella, james b. thomas, hernán a. navarro, james l. howard, gerald t. pollard, and f. ivy carroll. analogues of (3r)-7-hydroxy-n-[(1s)-1-{[(3r,4r)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide(jdtic). synthesis and in vitro and in vivo opioid receptor antagonist activity. j med chem. 2010 july, 53(14): 5290–5301.
[3] k. j. jackson, frank ivy carroll, s. s. negus and m. i. damaj. effect of the selective kappa-opioid receptor antagonist jdtic on nicotine antinociception, reward, and withdrawal in the mouse. psychopharmacology (berl). 2010 june, 210(2): 285–294.

JDTic (2HCl) Preparation Products And Raw materials

Raw materials

Preparation Products

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JDTic (2HCl) Suppliers

China 37 United States 8 Global 45

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785835-79-2, JDTic (2HCl)Related Search:

JDTic (dihydrochloride)

(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

JDTic (2HCl)

(3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide hydrochloride

(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride

CS-648

(3R)-7-hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride

(3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide

JDTic hydrochloride

785835-79-2

C28H39N3O32HCl

C28H41Cl2N3O3

tetrahydroisoqu