2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2)

Product Name: 2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2)
CAS No.: 451493-31-5
Chemical Name: 2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2)
Synonyms: MP-412;MP412;AV-412 / MP-412;AV-412 Tosylate;451492-95-8 (AV-412 FREE BASE);MP-412;AV412;AV 412;MP412;MP 412;AV412,EGFR,MP-412,Inhibitor,inhibit,MP 412,HER1,Epidermal growth factor receptor,AV 412,AV-412,ErbB-1;N-[4-(3-Chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide tosylate;N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide,4-methylbenzenesulfonic acid;N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate);N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-6-quinazolinyl]-2-propenamide bis(4-methylbenzenesulfonate)
CBNumber: CB02626693
Molecular Formula: C41H44ClFN6O7S2
Formula Weight: 851.4054632
MOL File: 451493-31-5.mol

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2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) Property

storage temp.: Store at -20°C
solubility: DMSO:21.5(Max Conc. mg/mL);25.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.29(Max Conc. mM)
DMF:15.0(Max Conc. mg/mL);17.64(Max Conc. mM)
Ethanol:0.25(Max Conc. mg/mL);0.29(Max Conc. mM)
form: Powder

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29039
Product name: AV-412
Packaging: 5mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 29039
Product name: AV-412
Packaging: 50mg
Price: $601
Updated: 2024/03/01

Cayman Chemical

Product number: 29039
Product name: AV-412
Packaging: 10mg
Price: $207
Updated: 2024/03/01

Cayman Chemical

Product number: 29039
Product name: AV-412
Packaging: 25mg
Price: $423
Updated: 2024/03/01

TRC

Product number: A794725
Product name: AV412
Packaging: 25mg
Price: $350
Updated: 2021/12/16

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2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) Chemical Properties,Usage,Production

Uses

AV 412 is EGFR/HER2 inhibitor. It can be used in pharmacological activity and biological study of light-??assisted small-??molecule screening against protein kinases.

Biological Activity

AV-412 (MP412) is an EGFR inhibitor with IC50 values of 0.75, 0.5, 0.79, 2.3 and 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

in vitro

AV-412 inhibits autophosphorylation of EGFR and ErbB2 with IC ₅₀ of 43 and 282 nM, respectively. It also inhibits epidermal growth factor (EGF)-dependent cell proliferation with an IC ₅₀ of 100 nM. It abrogates EGFR signaling in the gefitinib-resistant H1975 cell line, which harbors a double mutation of L858R and T790M in EGFR.

in vivo

In animal studies using cancer xenograft models, AV-412 (30 mg/kg) demonstrates complete inhibition of tumor growth of the A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively.

target

EGFR

0.75 nM (IC ₅₀ )

EGFR ^L858R

0.5 nM (IC ₅₀ )

EGFR ^T790M

0.79 nM (IC ₅₀ )

EGFR < sup> L858R/T790M

2.3 nM (IC ₅₀ )

ErbB2

19 nM (IC ₅₀ )

2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) Suppliers

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View Lastest Price from 2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) manufacturers

Career Henan Chemical Co

Product: N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide,4-methylbenzenesulfonic acid 451493-31-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

451493-31-5, 2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2)Related Search:

MP-412;MP412

451492-95-8 (AV-412 FREE BASE)

N-[4-(3-Chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide tosylate

MP-412;AV412;AV 412;MP412;MP 412

N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide,4-methylbenzenesulfonic acid

2-PropenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-Methyl-3-(4-Methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-, 4-Methylbenzenesulfonate (1:2)

AV-412 / MP-412

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-6-quinazolinyl]-2-propenamide bis(4-methylbenzenesulfonate)

AV-412 Tosylate

AV412,EGFR,MP-412,Inhibitor,inhibit,MP 412,HER1,Epidermal growth factor receptor,AV 412,AV-412,ErbB-1

N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate)

451493-31-5

C27H28ClFN6O2C7H8O3S

2C7H8O3SC27H28ClFN6O