ChemicalBook > CAS DataBase List > CVT-12012

CVT-12012

Product Name: CVT-12012
CAS No.: 1018675-35-8
Chemical Name: CVT-12012
Synonyms: CS-2863;CVT-2012;CVT-12012;CVT-12012, 10 mM in DMSO;CVT 12012,Stearoyl-CoA Desaturase (SCD),inhibit,CVT12012,Inhibitor,CVT-12012;2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamide;2-Hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]acetamide;Acetamide, 2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]-;2-Hydroxy-N-(2-(3-methyl-2-oxo-7-(((3-(trifluoromethyl)phenyl)methyl)amino)-1,2-dihydroquinoxalin-1-yl)ethyl)acetamide
CBNumber: CB02627711
Molecular Formula: C21H21F3N4O3
Formula Weight: 434.41
MOL File: 1018675-35-8.mol

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CVT-12012 Property

Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml; Ethanol: 1 mg/ml
form: A crystalline solid
pka: 13.29±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27156
Product name: CVT-12012
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27156
Product name: CVT-12012
Packaging: 25mg
Price: $533
Updated: 2024/03/01

Cayman Chemical

Product number: 27156
Product name: CVT-12012
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 27156
Product name: CVT-12012
Packaging: 10mg
Price: $243
Updated: 2024/03/01

AK Scientific

Product number: 3111DC
Product name: Cvt-12012
Packaging: 5mg
Price: $252
Updated: 2021/12/16

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CVT-12012 Chemical Properties,Usage,Production

Uses

CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.

in vivo

In a rat PK study, CVT-12012 demonstrates good oral bioavailability (78%). It appears that the oral absorption of CVT-12012 is not affected by a significant Pgp efflux, which is expected based on Caco-2 assay result. The plasma clearance of CVT-12012 is high (88 mL/min/kg) with elimination half-life of approximately 1 h^[1].

References

[1] Koltun DO, et al. Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4070-4. DOI:10.1016/j.bmcl.2009.06.017
[2] Atkinson KA, et al. N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1621-5. DOI:10.1016/j.bmcl.2011.01.113

CVT-12012 Preparation Products And Raw materials

Raw materials

Preparation Products

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1018675-35-8, CVT-12012Related Search:

CVT-12012

2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamide

CVT-2012

CS-2863

2-Hydroxy-N-(2-(3-methyl-2-oxo-7-(((3-(trifluoromethyl)phenyl)methyl)amino)-1,2-dihydroquinoxalin-1-yl)ethyl)acetamide

Acetamide, 2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]-

2-Hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]acetamide

CVT 12012,Stearoyl-CoA Desaturase (SCD),inhibit,CVT12012,Inhibitor,CVT-12012

CVT-12012, 10 mM in DMSO

1018675-35-8

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