EG00229

Product Name: EG00229
CAS No.: 1210945-69-9
Chemical Name: EG00229
Synonyms: CS-1273;EG00229;EG00229 TFA;EG00229,EG-00229;EG00229, 10 mM in DMSO;EG 00229 Trifluoroacetate;EG 00229 (trifluoroacetate salt);(S)-2-(3-(Benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-guanidinopentanoic acid 2,2,2-trifluoroacetate
CBNumber: CB02627791
Molecular Formula: C19H20F3N7O7S3
Formula Weight: 611.59
MOL File: 1210945-69-9.mol

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EG00229 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
color: Light yellow to yellow
InChIKey: ZYQBITUOSRZDTG-MERQFXBCSA-N
SMILES: FC(F)(F)C(=O)O.[S](=O)(=O)(Nc3c([s]cc3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)c1c2n[s]nc2ccc1

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3408
Product name: EG00229 trifluoroacetate
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $179
Updated: 2026/04/30

Sigma-Aldrich

Product number: SML3408
Product name: EG00229 trifluoroacetate
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $572
Updated: 2026/04/30

Cayman Chemical

Product number: 33937
Product name: EG 00229 (trifluoroacetate salt)
Purity: ≥98%
Packaging: 1mg
Price: $46
Updated: 2026/04/30

Cayman Chemical

Product number: 33937
Product name: EG 00229 (trifluoroacetate salt)
Purity: ≥98%
Packaging: 5mg
Price: $190
Updated: 2026/04/30

Cayman Chemical

Product number: 33937
Product name: EG 00229 (trifluoroacetate salt)
Purity: ≥98%
Packaging: 10mg
Price: $310
Updated: 2026/04/30

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EG00229 Chemical Properties,Usage,Production

Uses

EG 00229 Trifluoroacetic Acid Salt is an antagonist of the VEGFA receptor neuropilin (NRP1). This antagonism can result in the attenuation of prostate carcinoma cell proliferation.

Biological Activity

eg00229 is a small molecule inhibitor of neuropilin-1(nrp1) with an ic50 of 3μm [1].eg00229 has been reported to inhibit vegf-a binding to pae/nrp1 in the nrp1and bt-vegf-a binding to purified nrp1 b1 domain in a cell-free assay with an ic50 value of 8μm and 3μm, respectively. in addition, eg00229 has also shown the inhibition of vegf-a binding to vegfr2, vegfr1 and nrp1 in human umbilical vein endothelial cells (huvecs) in a dose-dependent manner with an ic50 value of 23μm [1]. besides, eg00229 has been revealed to prevent tuftsin binding to the nrp1 which is at the cell surface. moreover, eg00229 has been noted to suppress the anti-inflammatory m2 shift in microglia induced by tuftsin and thus potently prevent tuftsin’s action [2].

in vivo

EG00229 (0-10 mg/kg; intraperitoneal injection; three times per week; for 4 weeks; NSG mice) treatment substantially reduces tumor growth and visible vascularization^[2].

Animal Model:	6-week old female NOD scid IL2 receptor gamma chain knockout mice (NSG mice) with ECS cells^[2]
Dosage:	0 mg/kg, 10 mg/kg
Administration:	Intraperitoneal injection; three times per week; for 4 weeks
Result:	Reduces tumor growth and visible vascularization.

storage

Store at -20°C

References

[1] jarvis a1, allerston ck, jia h, herzog b, garza-garcia a, winfield n, ellard k, aqil r, lynch r, chapman c, hartzoulakis b, nally j, stewart m, cheng l, menon m, tickner m, djordjevic s, driscoll pc, zachary i, selwood dl.small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor a (vegf-a) interaction. j med chem. 2010 mar 11;53(5):2215-26.
[2] nissen jc1, selwood dl, tsirka se. tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. j neurochem. 2013 nov;127(3):394-402.

EG00229 Preparation Products And Raw materials

Raw materials

Preparation Products

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EG00229 Suppliers

China 63 India 1 United States 12 Global 76

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
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Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
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LETOPHARM LIMITED

Tel: +86-21-5821 5861
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Email: sales@letopharm.com
Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Guangzhou QiYun Biotechnology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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Email: 3008007409@qq.com
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Amadis Chemical Company Limited

Tel: 571-89925085
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Musechem

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Email: info@musechem.com
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Shandong utilizing biological technology co., LTD

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1210945-69-9, EG00229Related Search:

EG00229

CS-1273

EG 00229 Trifluoroacetate

EG00229 TFA

EG00229,EG-00229

EG 00229 (trifluoroacetate salt)

(S)-2-(3-(Benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-guanidinopentanoic acid 2,2,2-trifluoroacetate

EG00229, 10 mM in DMSO

1210945-69-9

C19H20F3N7O7S3