EPICOCHLIOQUINONE A

EPICOCHLIOQUINONE A Property

Boiling point:

638.8±55.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

pka

11.57±0.70(Predicted)

Hazard and Precautionary Statements (GHS)

EPICOCHLIOQUINONE A Chemical Properties,Usage,Production

Uses

Epicochlioquinone A can inhibit rat liver microsomal ACAT with IC50 of 1.7 μM, inhibit plasma lecithin cholesterol acyltransferase (LCAT) with IC50 of 15.8 μM, and inhibit cholesterol absorption in rats by 50% at 75 mg/kg[1].

Definition

ChEBI: Epi-cochlioquinone A is an organic heterotetracyclic that is 1,2,3,4a,5,6,6a,12,12a,12b-decahydropyrano[3,2-a]xanthene-8,11-dione substituted by a 2-hydroxypropan-2-yl group at position 3, hydroxy group at position 12, methyl groups at positions 6a and 12b and a 3-(acetyloxy)-4-methylhexan-2-yl moiety at position 9. Isolated from the fermentation broth of Stachybotrys bisbyi SANK 17777, it acts as an inhibitor of acyl-CoA:cholesterol acyltransferase. It has a role as a metabolite and an EC 2.3.1.26 (sterol O-acyltransferase) inhibitor. It is an organic heterotetracyclic compound, an acetate ester, a cyclic ether, a secondary alcohol, a tertiary alcohol and a member of p-quinones.

References

[1] T Fujioka, et al. Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi. J Antibiot (Tokyo). 1996 May;49(5):409-13.