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GSK163090

Product Name
GSK163090
CAS No.
844903-58-8
Chemical Name
GSK163090
Synonyms
CS-2298;GSK163090;GSK163090 (GSK-163090;GSK163090, 10 mM in DMSO;GSK163090; GSK-163090; GSK 163090.;5-HT1A/B/D receptor antagonist GS163090;1-(3-{2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl}phenyl)imidazolidin-2-one;1-[3-[2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl]phenyl]-2-imidazolidinone;2-Imidazolidinone,1-[3-[2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl]phenyl]-;Dopamine Receptor,5-HT1A,GSK163090,Inhibitor,5-hydroxytryptamine Receptor,antidepressant,anxiolytic,SerT,inhibit,5-HT1B,5-HT1D,5-HT Receptor,GSK-163090,GSK 163090,Serotonin Receptor,P-glycoprotein
CBNumber
CB02627928
Molecular Formula
C25H29N5O
Formula Weight
415.53
MOL File
844903-58-8.mol
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GSK163090 Property

Density 
1.216±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 16.5 mg/mL (39.71 mM)
form 
Solid
pka
14.20±0.20(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5315
Product name
GSK163090
Purity
99.95%
Packaging
5mg
Price
$190
Updated
2021/12/16
ChemScene
Product number
CS-5315
Product name
GSK163090
Purity
99.95%
Packaging
10mg
Price
$330
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013926
Product name
GSK-163090
Purity
95.00%
Packaging
5MG
Price
$504.57
Updated
2021/12/16
ChemScene
Product number
CS-5315
Product name
GSK163090
Purity
99.95%
Packaging
50mg
Price
$1050
Updated
2021/12/16
ChemScene
Product number
CS-5315
Product name
GSK163090
Purity
99.95%
Packaging
100mg
Price
$1750
Updated
2021/12/16
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GSK163090 Chemical Properties,Usage,Production

Uses

GSK163090 is a potent, selective and orally active 5-HT1A/1B/1D receptor antagonist with pKi values of 9.4/8.5/9.7, respectively. GSK163090 inhibits the functional activity of serotonin reuptake transporter (SerT) with a pKi value of 6.1. GSK163090 has antidepressant and anxiolytic activities[1].

in vivo

In male Sprague-Dawley rats, GSK163090 (compound 36) treatment shows clear dose-dependent inhibition of the 8-OH-DPAT-induced hyperlocomotor activity (hLMA), with ED50 values ranging from 0.03 to 1 mg/kg[1].

IC 50

5-HT1A Receptor: 9.4 (pKi); 5-HT1B Receptor: 8.5 (pKi); 5-HT1D Receptor: 9.7 (pKi); D2 Receptor: 6.3 (pKi); D3 Receptor: 6.7 (pKi); 5-HT2A Receptor: 6 (pKi); 5-HT2B Receptor: 6.3 (pKi); 5-HT2C Receptor: 5.8 (pKi); Human 5-HT6 Receptor: <5.3 (pKi); Human 5-HT7 Receptor: 6.8 (pKi)

References

[1] Leslie CP, et al. Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist. J Med Chem. 2010 Dec 9;53(23):8228-8240. DOI:10.1021/jm100714c

GSK163090 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK163090 Suppliers

China 47 United States 7 Global 54
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Fax
0571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
2028
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2989
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
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View Lastest Price from GSK163090 manufacturers

Career Henan Chemical Co
Product
GSK163090 844903-58-8
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

844903-58-8, GSK163090Related Search:

GS9620

  • GSK163090
  • 1-[3-[2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl]phenyl]-2-imidazolidinone
  • 2-Imidazolidinone,1-[3-[2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl]phenyl]-
  • GSK163090; GSK-163090; GSK 163090.
  • 5-HT1A/B/D receptor antagonist GS163090
  • CS-2298
  • GSK163090 (GSK-163090
  • Dopamine Receptor,5-HT1A,GSK163090,Inhibitor,5-hydroxytryptamine Receptor,antidepressant,anxiolytic,SerT,inhibit,5-HT1B,5-HT1D,5-HT Receptor,GSK-163090,GSK 163090,Serotonin Receptor,P-glycoprotein
  • 1-(3-{2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl}phenyl)imidazolidin-2-one
  • GSK163090, 10 mM in DMSO
  • 844903-58-8
  • C25H29N5O