L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)
- Product Name
- L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)
- CAS No.
- 685898-44-6
- Chemical Name
- L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)
- Synonyms
- CS-1467;PX-478 HCl;PX478 2HCl;ALKN004012;PX 478 DISCONTINUED;PX-478 dihydrochloride;4-[Bis(2-chloroethyl)oxidoamino]-L-phenylalanine dihydrochloride;4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine,hydrochloride (1:2);L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1;Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)
- CBNumber
- CB02628046
- Molecular Formula
- C13H19Cl3N2O3
- Formula Weight
- 357.66
- MOL File
- 685898-44-6.mol
L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2) Property
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- ≥19.7 mg/mL in DMSO; ≥50 mg/mL in H2O; ≥8.42 mg/mL in EtOH
- form
- Powder
- CAS DataBase Reference
- 685898-44-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 10005189
- Product name
- PX-478
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $66
- Updated
- 2024/03/01
- Product number
- 10005189
- Product name
- PX-478
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $387
- Updated
- 2024/03/01
- Product number
- 10005189
- Product name
- PX-478
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $30
- Updated
- 2021/12/16
- Product number
- 10005189
- Product name
- PX-478
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 10005189
- Product name
- PX-478
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $259
- Updated
- 2024/03/01
L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2) Chemical Properties,Usage,Production
Uses
PX 478 is a HIF-1α inhibitor that may be used in cancer therapy for treatment of solid tumors. PX478 has also been shown to suppress high-fat-diet (HFD)-induced HIFα activation in adipose tissue in mice and therefore may be used to ameliorate adipose tissue dysfunction.
Biological Activity
px-478 2hcl, also called px-478, is an experimental hif-1α inhibitor. it inhibited hif-1α protein at multiple levels in cancer cell lines under normoxia and hypoxia with an ic50 value of ~20-30 μm [1].hypoxia-inducible transcription factor hif-1α activates target genes involved in glycolysis, erythropoiesis and angiogenesis. hif-1α also regulates the expression of genes coding for apoptotic pathway, growth factors/receptors, cell cycle regulators, metastasis and invasiveness [1].under normoxic condition, the ic50 for px-478 to inhibit hif-1α in pc3 cells was 20-25 μmol/l, whereas the ic50 for px-478 to inhibit hif-1α in the du 145 cells was ~40-50 μmol/l. in both du 145 and pc3 cells, 1-hr hypoxia significantly upregulated hif-1α protein. but the pretreatment with px-478 for 20 hr under normoxia before 1-hr hypoxia attenuated the accumulation of hif-1α induced by the 1-hr hypoxia. in pc3 cells, pretreatment with 20 μmol/l px-478 before hypoxia inhibited hif-1α by 40% compared to treatment with hypoxia alone. in du 145 cells, pretreatment with 50 μmol/l px-478 before hypoxia inhibited hif-1α by 35% compared to treatment with hypoxia alone [1].in nu/nu mice with c6 reporter xenografts, treatment with px-478 at a dose of 30 mg/kg p.o. for 2 consecutive days prevented the transcriptional activity of hif-1 in central ischemic regions of c6 tumors [2].
References
[1]. palayoor st, mitchell jb, cerna d, et al. px-478, an inhibitor of hypoxia-inducible factor-1α, enhances radiosensitivity of prostate carcinoma cells. international journal of cancer, 2008, 123(10): 2430-2437.
[2]. schwartz dl, powis g, thitai-kumar a, et al. the selective hypoxia inducible factor-1 inhibitor px-478 provides in vivo radiosensitization through tumor stromal effects. molecular cancer therapeutics, 2009, 8(4): 947-958.
L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2) Preparation Products And Raw materials
Raw materials
Preparation Products
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