L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)

Product Name: L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)
CAS No.: 685898-44-6
Chemical Name: L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)
Synonyms: CS-1467;PX-478 HCl;PX478 2HCl;ALKN004012;PX478 2HCI;PX 478 DISCONTINUED;PX-478 dihydrochloride;4-[Bis(2-chloroethyl)oxidoamino]-L-phenylalanine dihydrochloride;4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine,hydrochloride (1:2);L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1
CBNumber: CB02628046
Molecular Formula: C13H19Cl3N2O3
Formula Weight: 357.66
MOL File: 685898-44-6.mol

More

Less

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2) Property

storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: ≥19.7 mg/mL in DMSO; ≥50 mg/mL in H2O; ≥8.42 mg/mL in EtOH
form: Powder
color: Off-white to yellow
CAS DataBase Reference: 685898-44-6

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 10005189
Product name: PX-478
Purity: ≥95%
Packaging: 5mg
Price: $66
Updated: 2024/03/01

Cayman Chemical

Product number: 10005189
Product name: PX-478
Purity: ≥95%
Packaging: 50mg
Price: $387
Updated: 2024/03/01

Cayman Chemical

Product number: 10005189
Product name: PX-478
Purity: ≥95%
Packaging: 1mg
Price: $30
Updated: 2021/12/16

Cayman Chemical

Product number: 10005189
Product name: PX-478
Purity: ≥95%
Packaging: 10mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 10005189
Product name: PX-478
Purity: ≥95%
Packaging: 25mg
Price: $259
Updated: 2024/03/01

More

Less

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2) Chemical Properties,Usage,Production

Uses

PX 478 is a HIF-1α inhibitor that may be used in cancer therapy for treatment of solid tumors. PX478 has also been shown to suppress high-fat-diet (HFD)-induced HIFα activation in adipose tissue in mice and therefore may be used to ameliorate adipose tissue dysfunction.

Biological Activity

px-478 2hcl, also called px-478, is an experimental hif-1α inhibitor. it inhibited hif-1α protein at multiple levels in cancer cell lines under normoxia and hypoxia with an ic50 value of ~20-30 μm [1].hypoxia-inducible transcription factor hif-1α activates target genes involved in glycolysis, erythropoiesis and angiogenesis. hif-1α also regulates the expression of genes coding for apoptotic pathway, growth factors/receptors, cell cycle regulators, metastasis and invasiveness [1].under normoxic condition, the ic50 for px-478 to inhibit hif-1α in pc3 cells was 20-25 μmol/l, whereas the ic50 for px-478 to inhibit hif-1α in the du 145 cells was ~40-50 μmol/l. in both du 145 and pc3 cells, 1-hr hypoxia significantly upregulated hif-1α protein. but the pretreatment with px-478 for 20 hr under normoxia before 1-hr hypoxia attenuated the accumulation of hif-1α induced by the 1-hr hypoxia. in pc3 cells, pretreatment with 20 μmol/l px-478 before hypoxia inhibited hif-1α by 40% compared to treatment with hypoxia alone. in du 145 cells, pretreatment with 50 μmol/l px-478 before hypoxia inhibited hif-1α by 35% compared to treatment with hypoxia alone [1].in nu/nu mice with c6 reporter xenografts, treatment with px-478 at a dose of 30 mg/kg p.o. for 2 consecutive days prevented the transcriptional activity of hif-1 in central ischemic regions of c6 tumors [2].

References

[1]. palayoor st, mitchell jb, cerna d, et al. px-478, an inhibitor of hypoxia-inducible factor-1α, enhances radiosensitivity of prostate carcinoma cells. international journal of cancer, 2008, 123(10): 2430-2437.
[2]. schwartz dl, powis g, thitai-kumar a, et al. the selective hypoxia inducible factor-1 inhibitor px-478 provides in vivo radiosensitization through tumor stromal effects. molecular cancer therapeutics, 2009, 8(4): 947-958.

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2) Suppliers

China 67 United States 12 Global 79

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

International Laboratory Limited

Tel: --
Fax: --
Email: admin@intlab.org
Country: United States
ProdList: 5356
Advantage: 50

685898-44-6, L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)Related Search:

Sulfanilamide 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol N,N'-Ethylenebis(stearamide) Alectinib 2-METHOXYESTRADIOL Infigratinib BAY 87-2243 Sunitinib Malate Doxorubicin hydrochloride

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)

PX-478 dihydrochloride

PX478 2HCl

4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine,hydrochloride (1:2)

PX-478 HCl

Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2)

4-[Bis(2-chloroethyl)oxidoamino]-L-phenylalanine dihydrochloride

(S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride

PX-478; L-PHENYLALANINE; 4-[BIS(2-CHLOROETHYL)OXIDOAMINO]-; DIHYDROCHLORIDE; L-PHENYLALANINE; 4-[BIS(2-CHLOROETHYL)OXIDOAMINO]-; HYDROCHLORIDE (1:2).

CS-1467

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1

PX 478 DISCONTINUED

(S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)cyclohexa-1,3-dienamine oxide dihydrochloride

ALKN004012

Inhibitor,Autophagy,HIFs,inhibit,PX-478,PX 478,HIF-PH,HIF/HIF Prolyl-Hydroxylase,PX478,Hypoxia-inducible factors

PX478 2HCI

685898-44-6

C13H18Cl2N2O32HCl

C13H20Cl4N2O3