MK-5046

Product Name: MK-5046
CAS No.: 1022152-70-0
Chemical Name: MK-5046
Synonyms: CS-2034;MK-5046;MK5046 peak 2;(2S)-1,1,1-TRIFLUORO-2-(4-PYRAZOL-1-YLPHENYL)-3-[5-[[1-(TRIFLUOROMETHYL)CYCLOPROPYL]METHYL]-1H-IMIDAZOL-2-YL]PROPAN-2-OL;1H-Imidazole-2-ethanol, α-[4-(1H-pyrazol-1-yl)phenyl]-α-(trifluoromethyl)-5-[[1-(trifluoromethyl)cyclopropyl]methyl]-, (αS)-;(2S)-1,1,1-Trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]-3-(4-{[1-(trif luoromethyl)cyclopropyl]methyl}-1H-imidazol-2-yl)-2-propanol;(alphaS)-alpha-[4-(1H-Pyrazol-1-yl)phenyl]-alpha-(trifluoromethyl)-5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1H-imidazole-2-ethanol
CBNumber: CB02628147
Molecular Formula: C20H18F6N4O
Formula Weight: 444.38
MOL File: 1022152-70-0.mol

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MK-5046 Property

Boiling point:: 571.6±50.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 11.22±0.15(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-4808
Product name: MK-5046
Purity: 99.67%
Packaging: 5mg
Price: $360
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0014018
Product name: MK-5046
Purity: 95.00%
Packaging: 5MG
Price: $500.27
Updated: 2021/12/16

ChemScene

Product number: CS-4808
Product name: MK-5046
Purity: 99.67%
Packaging: 10mg
Price: $528
Updated: 2021/12/16

ChemScene

Product number: CS-4808
Product name: MK-5046
Purity: 99.67%
Packaging: 100mg
Price: $2340
Updated: 2021/12/16

Crysdot

Product number: CD31004816
Product name: MK-5046
Purity: 98+%
Packaging: 5mg
Price: $210
Updated: 2021/12/16

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MK-5046 Chemical Properties,Usage,Production

Uses

MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity[1][2][3].

in vivo

MK-5046 (3, 10 and 30 mg/kg; oral administration for once) inhibits food intake, and increases resting metabolic rate (MR) and body temperature in DIO mice^[1]. MK-5046 (5, 25 and 50 mg/kg; s.c. once daily for 14 days) significantly reduces body weight and food intake in DIO mice^[1].

Animal Model:	Male C57BL/6N mice with high-fat diet for the diet-induced obese (DIO) model^[1]
Dosage:	3, 10 and 30 mg/kg
Administration:	Oral administration; 3, 10 and 30 mg/kg for once
Result:	Dose-dependently inhibited food intake at 2 h and overnight in DIO mice. But showed no effect on Brs3 knockout mice.

References

[1] Guan XM, et al. Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist. J Pharmacol Exp Ther. 2011 Feb;336(2):356-364. DOI:10.1124/jpet.110.174763
[2] Sebhat IK, et al. Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett. 2010 Oct 18;2(1):43-47. DOI:10.1021/ml100196d
[3] Ramos-Alvarez I, et al. The Nonpeptide Agonist MK-5046 Functions As an Allosteric Agonist for the Bombesin Receptor Subtype-3. J Pharmacol Exp Ther. 2022 Aug;382(2):66-78. DOI:10.1124/jpet.121.001033

MK-5046 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-5046 Suppliers

China 43 United States 8 Global 51

Shanghai Boyle Chemical Co., Ltd.

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1022152-70-0, MK-5046Related Search:

MK-5046

MK5046 peak 2

(2S)-1,1,1-TRIFLUORO-2-(4-PYRAZOL-1-YLPHENYL)-3-[5-[[1-(TRIFLUOROMETHYL)CYCLOPROPYL]METHYL]-1H-IMIDAZOL-2-YL]PROPAN-2-OL

(alphaS)-alpha-[4-(1H-Pyrazol-1-yl)phenyl]-alpha-(trifluoromethyl)-5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1H-imidazole-2-ethanol

CS-2034

(2S)-1,1,1-Trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]-3-(4-{[1-(trif luoromethyl)cyclopropyl]methyl}-1H-imidazol-2-yl)-2-propanol

1H-Imidazole-2-ethanol, α-[4-(1H-pyrazol-1-yl)phenyl]-α-(trifluoromethyl)-5-[[1-(trifluoromethyl)cyclopropyl]methyl]-, (αS)-

1022152-70-0

1055152-70-0

C20H18F6N4O

Inhibitors