RX-3117

Product Name: RX-3117
CAS No.: 865838-26-2
Chemical Name: RX-3117
Synonyms: TV1360;CS-1677;TV-1360;TV 1360;RX-3117;Roducitabine;RX-3117 (TV-1360);RX-3117, 10 mM in DMSO;TV-1360;FLUOROCYCLOPENTENYLCYTOSINE;RX-3117; RX3117; RX 3117; TV-1360; TV1360; TV 1360; FLUOROCYCLOPENTENYLCYTOSINE
CBNumber: CB02628369
Molecular Formula: C10H12FN3O4
Formula Weight: 257.22
MOL File: 865838-26-2.mol

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RX-3117 Property

Boiling point:: 516.3±60.0 °C(Predicted)
Density: 1.82±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:50.0(Max Conc. mg/mL);194.39(Max Conc. mM)
pka: 12.88±0.70(Predicted)
form: Powder
color: White to off-white
InChI: InChI=1S/C10H12FN3O4/c11-6-4(3-15)8(16)9(17)7(6)14-2-1-5(12)13-10(14)18/h1-2,7-9,15-17H,3H2,(H2,12,13,18)/t7-,8-,9+/m1/s1
InChIKey: QLLGKCJUPWYJON-HLTSFMKQSA-N
SMILES: C1(=O)N([C@H]2[C@H](O)[C@H](O)C(CO)=C2F)C=CC(N)=N1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3947
Product name: RX-3117
Purity: 98.38%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-3947
Product name: RX-3117
Purity: 98.38%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-3947
Product name: RX-3117
Purity: 98.38%
Packaging: 50mg
Price: $2520
Updated: 2021/12/16

Crysdot

Product number: CD31000518
Product name: RX-3117
Purity: 98+%
Packaging: 5mg
Price: $245
Updated: 2021/12/16

Crysdot

Product number: CD31000518
Product name: RX-3117
Purity: 98+%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

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RX-3117 Chemical Properties,Usage,Production

Uses

RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis[1][2][3].

Definition

ChEBI: Roducitabine is a triol that is (1S,2R)-4-fluoro-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol which is substituted by a 4-amino-2-oxopyrimidin-1(2H)-yl group at position 5. It is a cytidine analog which exhibits anticancer activity in several cancers, including gemcitabine-resistant tumours. It has a role as an antimetabolite, an antineoplastic agent, a prodrug, a DNA synthesis inhibitor and an apoptosis inducer. It is an organofluorine compound, a primary allylic alcohol and a triol.

in vivo

RX-3117 (2, 10 mg/kg; i.p.; three times per week for five weeks) shows anti-tumour activity in nude mice^[3].

Animal Model:	Nude mice (human colon carcinoma HCT116 xenograft model)^[3]
Dosage:	2, 10 mg/kg
Administration:	I.p.; three times per week for five weeks
Result:	Caused significant inhibition of tumor growth at the doses of 2 and 10 mg/kg.

References

[1] Sarkisjan D, et al. The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2. PLoS One. 2016 Sep 9;11(9):e0162901. DOI:10.1371/journal.pone.0162901
[2] Balboni B, et al. RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment. Expert Opin Investig Drugs. 2019 Apr;28(4):311-322. DOI:10.1080/13543784.2019.1583742
[3] Fahy J, et al. DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies. Expert Opin Ther Pat. 2012 Dec;22(12):1427-42. DOI:10.1517/13543776.2012.729579

RX-3117 Preparation Products And Raw materials

Raw materials

Preparation Products

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RX-3117 Suppliers

China 61 United States 7 Global 68

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865838-26-2, RX-3117Related Search:

RX-3117 (TV-1360)

RX-3117

4-Amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-2(1H)-pyrimidinone

TV-1360;FLUOROCYCLOPENTENYLCYTOSINE

RX-3117; RX3117; RX 3117; TV-1360; TV1360; TV 1360; FLUOROCYCLOPENTENYLCYTOSINE

TV 1360

TV1360

TV-1360

CS-1677

2(1H)-Pyrimidinone, 4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-

Nucleoside Antimetabolite/Analog,RX3117,S phase,DNMT1,TV1360,inhibit,orally active,RX-3117,TV 1360,apoptosis,antiproliferative,RX 3117,Inhibitor,anti-tumour

RX-3117, 10 mM in DMSO

Roducitabine

865838-26-2