SCH1473759 (HCl salt)

Product Name: SCH1473759 (HCl salt)
CAS No.: 1094067-13-6
Chemical Name: SCH1473759 (HCl salt)
Synonyms: SCH-1473759 HCl;SCH1473759 (HCl salt);SCH-1473759 hydrochloride;SCH-1473759 hydrochloride /1094067-13-6;Aurora Kinase,inhibit,SCH1473759,Inhibitor,SCH 1473759,SCH1473759 hydrochloride,SCH 1473759 hydrochloride,SCH-1473759
CBNumber: CB02628389
Molecular Formula: C20H27ClN8OS
Formula Weight: 463
MOL File: 1094067-13-6.mol

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SCH1473759 (HCl salt) Property

storage temp.: Store at -20°C
solubility: DMSO: 70 mg/mL (151.19 mM)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3477
Product name: SCH-1473759hydrochloride
Purity: 99.67%
Packaging: 2mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-3477
Product name: SCH-1473759hydrochloride
Purity: 99.67%
Packaging: 5mg
Price: $264
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611479
Product name: SCH-1473759 hydrochloride
Packaging: 5mg
Price: $368.9
Updated: 2021/12/16

ChemScene

Product number: CS-3477
Product name: SCH-1473759hydrochloride
Purity: 99.67%
Packaging: 10mg
Price: $384
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000833
Product name: SCH-1473759 HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $500.65
Updated: 2021/12/16

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SCH1473759 (HCl salt) Chemical Properties,Usage,Production

Uses

SCH-1473759 hydrochloride is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.

in vivo

SCH-1473759 at a low dose of 5 mg/kg (ip, bid) is well-tolerated in a continuous dosing schedule and shows 50% tumor growth inhibition(TGI) on day 16. A higher dose of 10mg/kg(ip, bid) is well-tolerated in an intermittent schedule (5 days on, 5 days off) and gave 69% TGI on day 16. SCH-1473759 shows good exposure in all species with the clearance being high in rodents and moderate in dog and monkey. The half-life is also moderate, but the tissue distribution is high^[1]. SCH 1473759 dose- and schedule-dependent anti-tumor activity in four human tumor xenograft models. Further, the efficacy is enhanced in combination with taxanes and found to be most efficacious when SCH 1473759 is dosed 12-h post-taxane treatment^[2].

IC 50

Aurora A: 4 nM (IC₅₀); Aurora B: 13 nM (IC₅₀)

References

[1] Yu T, et al. Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8. DOI:10.1021/ml100063w
[2] Basso AD, et al. SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33. DOI:10.1007/s00280-011-1568-1

SCH1473759 (HCl salt) Preparation Products And Raw materials

Raw materials

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1094067-13-6, SCH1473759 (HCl salt)Related Search:

SCH1473759 (HCl salt)

SCH-1473759 hydrochloride

SCH-1473759 HCl

Aurora Kinase,inhibit,SCH1473759,Inhibitor,SCH 1473759,SCH1473759 hydrochloride,SCH 1473759 hydrochloride,SCH-1473759

SCH-1473759 hydrochloride /1094067-13-6

1094067-13-6