N-Methoxy-N,1-diMethylpiperidine-4-carboxaMide
- Product Name
- N-Methoxy-N,1-diMethylpiperidine-4-carboxaMide
- CAS No.
- 215950-19-9
- Chemical Name
- N-Methoxy-N,1-diMethylpiperidine-4-carboxaMide
- Synonyms
- N-Methoxy-N,1-diMethylpiperidine-4-carboxaMide;N-methoxy-N, 1-dimethylpiperidin-4-carboxamide;1-methyl-4-[Methoxy(Methyl)carbamoyl]piperidine;4-Piperidinecarboxamide, N-methoxy-N,1-dimethyl-;N-Methoxy-N,1-dimethylpiperidine-4-carboxamide 95+%;1-methyl-piperidine-4-carboxylicacidmethoxy-methyl-amide
- CBNumber
- CB02630720
- Molecular Formula
- C9H18N2O2
- Formula Weight
- 186.25
- MOL File
- 215950-19-9.mol
N-Methoxy-N,1-diMethylpiperidine-4-carboxaMide Property
- Boiling point:
- 235.3±50.0 °C(Predicted)
- Density
- 1.041±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.41±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C9H18N2O2/c1-10-6-4-8(5-7-10)9(12)11(2)13-3/h8H,4-7H2,1-3H3
- InChIKey
- HPSNOVOYRZPVAW-UHFFFAOYSA-N
- SMILES
- N1(C)CCC(C(N(OC)C)=O)CC1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 4H48-1-XE
- Product name
- N-Methoxy-N,1-dimethylpiperidine-4-carboxamide
- Packaging
- 250mg
- Price
- $232
- Updated
- 2021/12/16
- Product number
- CHM0393619
- Product name
- N-METHOXY-N,1-DIMETHYLPIPERIDINE-4-CARBOXAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.87
- Updated
- 2021/12/16
- Product number
- 4H48-1-XE
- Product name
- N-Methoxy-N,1-dimethylpiperidine-4-carboxamide
- Packaging
- 1g
- Price
- $575
- Updated
- 2021/12/16
- Product number
- 4H48-1-XE
- Product name
- N-Methoxy-N,1-dimethylpiperidine-4-carboxamide
- Packaging
- 5G
- Price
- $1724
- Updated
- 2021/12/16
- Product number
- CD11165266
- Product name
- N-Methoxy-N,1-dimethylpiperidine-4-carboxamide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1132
- Updated
- 2021/12/16
N-Methoxy-N,1-diMethylpiperidine-4-carboxaMide Chemical Properties,Usage,Production
Synthesis
68947-43-3
6638-79-5
215950-19-9
The general procedure for the synthesis of N-methoxy-N,1-dimethylpiperidine-4-carboxamide from 1-methylpiperidine-4-carboxylic acid and N,O-dimethylhydroxylamine hydrochloride was as follows: 1-methylpiperidine-4-carboxylic acid (5.5 g, 38.4 mmol) was dissolved in N,N-dimethylformamide (100 mL) under heating conditions. N,N-diisopropylethylamine (8.0 mL, 46.1 mmol), 1-hydroxybenzotriazole (5.2 g, 38.4 mmol), and N,O-dimethylhydroxylamine hydrochloride (4.1 g, 42.2 mmol) were added sequentially and the reaction mixture was stirred for 5 minutes. Subsequently, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (7.4 g, 38.4 mmol) was added, and the resulting homogeneous solution was stirred at room temperature for 63 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in water and the pH was adjusted to 9 with 5 N sodium hydroxide solution.The aqueous phase was extracted with dichloromethane, followed by washing with saturated sodium chloride solution and extraction with a solvent mixture of chloroform/isopropanol (3:1). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 9.5 g of yellow liquid product. Purification by fast column chromatography (silica gel as stationary phase, eluent dichloromethane:methanol:ammonium hydroxide=100:10:1) gave 5.7 g (80% yield) of light yellow liquid product. Mass spectrometry (MS) showed m/e: 186 (M+). The results of elemental analysis were consistent with the theoretical value of C9H18N2O2.
References
[1] Patent: US6777428, 2004, B1. Location in patent: Page column 24-25
N-Methoxy-N,1-diMethylpiperidine-4-carboxaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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