N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

Product Name: N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide
CAS No.: 1211565-08-0
Chemical Name: N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide
Synonyms: Rawal Squaramide Organocatalyst;N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide;N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N'-[4-(trifluoromethyl)phenyl]squaramide 95%;3-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione;3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione;3-Cyclobutene-1,2-dione, 3-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-;3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4- (trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione,99%e.e.;3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)
CBNumber: CB02638504
Molecular Formula: C22H26F3N3O2
Formula Weight: 421.46
MOL File: 1211565-08-0.mol

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N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide Property

Melting point:: 250 °C (decomp)
Boiling point:: 497.4±55.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
pka: 8.97±0.20(Predicted)
optical activity: [α]/D -42.0±2.0°, c = 1 in DMSO

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Safety

Hazard Codes: C
Risk Statements: 37/38-41
Safety Statements: 26-39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 728357
Product name: N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide
Purity: 95%
Packaging: 100mg
Price: $165
Updated: 2024/03/01

Sigma-Aldrich

Product number: 728357
Product name: N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide
Purity: 95%
Packaging: 500mg
Price: $466
Updated: 2024/03/01

Strem Chemicals

Product number: 07-1356
Product name: 3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)
Packaging: 50mg
Price: $102
Updated: 2024/03/01

ChemScene

Product number: CS-0092942
Product name: 3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione
Packaging: 100mg
Price: $142
Updated: 2021/12/16

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N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide Chemical Properties,Usage,Production

Uses

It can act as a catalyst for the asymmetric tandem aza-Michael addition-protonation between 1-nitro cyclohexene and 4-methoxyaniline to form the corresponding α-arylamino-β-nitro cyclohexane in a 35:65 trans/cis mixture.

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide Suppliers

China 21 United States 3 Global 24

Adamas Reagent, Ltd.

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Sigma-Aldrich

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Shanghai Chiral bio-compound co., Ltd.

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1211565-08-0, N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMideRelated Search:

3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]aMino]-3-Cyclobutene-1,2-dione 3-[[(9R)-6'-Methoxycinchonan-9-yl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione 3-[[(1S,2S)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione 3-[[(1S,2S)-2-aMinocyclohexyl]aMino]-4-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione 3-[[(8α,9S)-6'-Methoxycinchonan-9-yl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

3-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione

Rawal Squaramide Organocatalyst

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N'-[4-(trifluoromethyl)phenyl]squaramide 95%

3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4- (trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione,99%e.e.

3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)

3-Cyclobutene-1,2-dione, 3-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-

3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione

1211565-08-0