N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE

Product Name: N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE
CAS No.: 1083326-75-3
Chemical Name: N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE
Synonyms: 6-Methoxy-5-(methylsulfonamido)pyridine-3-boronic acid pinacol ester;N-(2-Methoxy-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)MethanesulfonaMide;N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE;Methanesulfonamide, N-[2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-;N-[2-(Methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]methanesulfonamide
CBNumber: CB02640677
Molecular Formula: C13H21BN2O5S
Formula Weight: 328.19
MOL File: 1083326-75-3.mol

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N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE Property

Boiling point:: 452.8±55.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 6.62±0.50(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C13H21BN2O5S/c1-12(2)13(3,4)21-14(20-12)9-7-10(16-22(6,17)18)11(19-5)15-8-9/h7-8,16H,1-6H3
InChIKey: NLKPUGUGRJNIMU-UHFFFAOYSA-N
SMILES: CS(NC1=CC(B2OC(C)(C)C(C)(C)O2)=CN=C1OC)(=O)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B426623
Product name: N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide
Packaging: 1g
Price: $60
Updated: 2021/12/16

TRC

Product number: B426623
Product name: N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide
Packaging: 5g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: 1690AA
Product name: N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide
Packaging: 250mg
Price: $347
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0007267
Product name: N-(2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-3-YL)METHANESULFONAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $498.65
Updated: 2021/12/16

Matrix Scientific

Product number: 185399
Product name: N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide
Purity: 95%
Packaging: 1g
Price: $619
Updated: 2021/12/16

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N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE Chemical Properties,Usage,Production

Synthesis

1083327-58-5

73183-34-3

1083326-75-3

GENERAL STEPS: N-(5-bromo-2-methoxypyridin-3-yl)methanesulfonamide (3.35 g, 11.9 mmol) and pinacol ester of bisboronic acid (4.24 g, 16.7 mmol) were suspended in toluene (100 mL), degassed and displaced three times with nitrogen. Tris(dibenzylideneacetone)dipalladium (616 mg, 0.595 mmol) and triphenylphosphine (243 mg, 0.892 mmol) were then added. The mixture was heated to 45 °C and stirred for 45 min, then potassium acetate (3.74 g, 23.8 mmol) was added. The reaction mixture was heated to reflux and stirring was continued for 3 hours. After completion of the reaction, it was cooled to room temperature, diluted with ethyl acetate (100 mL) and filtered through diatomaceous earth. The filtrate was washed sequentially with water (70 mL x 3) and saturated brine (100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate, v/v=2/1) to afford N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methane sulfonamide as a white solid (2.90 g, 74%). Mass spectrum (ESI, cation mode) m/z: 328.9 [M + H]+; 1H NMR (600 MHz, CDCl3): δ 8.32 (d, J=1.4 Hz, 1H), 8.06 (d, J=1.3 Hz, 1H), 6.66 (br s, 1H), 4.05 (s, 3H), 3.02 (s, 3H), 1.33 (s. 12H).

References

[1] Organic Process Research and Development, 2018, vol. 22, # 3, p. 368 - 376
[2] Patent: US2014/134133, 2014, A1. Location in patent: Paragraph 0441
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 3, p. 637 - 646
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 6087 - 6109
[5] European Journal of Medicinal Chemistry, 2018, vol. 146, p. 460 - 470

N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE Suppliers

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1083326-75-3, N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDERelated Search:

6-Methoxy-5-(methylsulfonamido)pyridine-3-boronic acid pinacol ester

N-[2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINYL]-METHANESULFONAMIDE

N-(2-Methoxy-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)MethanesulfonaMide

N-[2-(Methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]methanesulfonamide

Methanesulfonamide, N-[2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-

1083326-75-3

C13H21BN2O5S