6-broMo-2,3-dihydro-1H-inden-5-ol
- Product Name
- 6-broMo-2,3-dihydro-1H-inden-5-ol
- CAS No.
- 32337-85-2
- Chemical Name
- 6-broMo-2,3-dihydro-1H-inden-5-ol
- Synonyms
- 6-Bromoindan-5-ol;6-broMo-2,3-dihydro-1H-inden-5-ol;1H-Inden-5-ol, 6-broMo-2,3-dihydro-
- CBNumber
- CB02644266
- Molecular Formula
- C9H9BrO
- Formula Weight
- 213.07
- MOL File
- 32337-85-2.mol
6-broMo-2,3-dihydro-1H-inden-5-ol Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A109380
- Product name
- 6-Bromo-2,3-dihydro-1H-inden-5-ol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $86
- Updated
- 2021/12/16
- Product number
- 32337852
- Product name
- 6-Bromo-2,3-dihydro-1H-inden-5-ol
- Packaging
- 1g
- Price
- $198
- Updated
- 2021/12/16
- Product number
- CM252204
- Product name
- 6-Bromo-2,3-dihydro-1H-inden-5-ol
- Purity
- 95%
- Packaging
- 1g
- Price
- $204
- Updated
- 2021/12/16
- Product number
- A109380
- Product name
- 6-Bromo-2,3-dihydro-1H-inden-5-ol
- Purity
- 98%
- Packaging
- 1g
- Price
- $212
- Updated
- 2021/12/16
- Product number
- CM252204
- Product name
- 6-Bromo-2,3-dihydro-1H-inden-5-ol
- Purity
- 95%
- Packaging
- 5g
- Price
- $561
- Updated
- 2021/12/16
6-broMo-2,3-dihydro-1H-inden-5-ol Chemical Properties,Usage,Production
Synthesis
1470-94-6
32337-84-1
32337-85-2
5-Indanol (268 g, 2 mmol) was dissolved in 400 mL of N,N-dimethylformamide (DMF) and cooled to 0°C. N-bromosuccinimide (NBS) (2.1 mmol) was added in batches and reacted for 6 h while maintaining the reaction temperature at about 2°C. The reaction was carried out by TLC. The progress of the reaction was monitored by TLC during the reaction. After completion of the reaction, the reaction mixture was poured into 3 L of water and extracted with ethyl acetate (500 mL × 4). The organic phases were combined and washed sequentially with 1N hydrochloric acid solution (500 mL × 2) and saturated brine (500 mL × 2), then dried with anhydrous sodium sulfate. After concentration under reduced pressure, a brown oil was obtained. The light fraction was separated by molecular distillation (conditions: 70 °C, 100 Pa) to afford 4-bromo-2,3-dihydro-1H-inden-5-ol (103.8 g). Further molecular distillation of the recombinant fraction (conditions: 75 °C, 100 Pa) afforded 6-bromo-2,3-dihydro-1H-inden-5-ol (84.5 g). The structure of the product was determined by 1H-NMR (600 MHz, DMSO-d6, δ ppm: 7.49 (d, 1H, J = 7.2 Hz), 7.41 (d, 1H, J = 7.2 Hz), 5.07 (s, 1H), 3.05 (t, 2H), 2.98 (t, 2H), 2.12 (m, 2H)) and ESI-MS (m/z: [M + H]+ 214.0) were confirmed.
References
[1] Patent: WO2003/91225, 2003, A1. Location in patent: Page/Page column 57
[2] Journal of Organic Chemistry, 2015, vol. 80, # 18, p. 9292 - 9296
[3] Patent: CN103910718, 2018, B. Location in patent: Paragraph 0122-0125
6-broMo-2,3-dihydro-1H-inden-5-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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