ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE
- Product Name
- ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE
- CAS No.
- 1227934-69-1
- Chemical Name
- ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE
- Synonyms
- Ethyl 2-bromo-4-(trifluoromethyl)oxazole-5-carboxylat;ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE;ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)-1,3-OXAZOLE-5-CARBOXYLATE;5-Oxazolecarboxylic acid, 2-bromo-4-(trifluoromethyl)-, ethyl ester
- CBNumber
- CB02646932
- Molecular Formula
- C7H5BrF3NO3
- Formula Weight
- 288.02
- MOL File
- 1227934-69-1.mol
ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE Property
- Boiling point:
- 297.5±50.0 °C(Predicted)
- Density
- 1.698±0.06 g/cm3(Predicted)
- pka
- -6.06±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E938228
- Product name
- Ethyl2-Bromo-4-(trifluoromethyl)oxazole-5-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 9360BB
- Product name
- Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate
- Packaging
- 250mg
- Price
- $281
- Updated
- 2021/12/16
- Product number
- 9360BB
- Product name
- Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate
- Packaging
- 1g
- Price
- $616
- Updated
- 2021/12/16
- Product number
- 10-2548
- Product name
- ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate
- Purity
- 95%-98%
- Packaging
- 1g
- Price
- $764
- Updated
- 2021/12/16
- Product number
- CM248363
- Product name
- Ethyl2-bromo-4-(trifluoromethyl)oxazole-5-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $1449
- Updated
- 2021/12/16
ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
135026-17-4
1227934-69-1
Step 2: Ethyl 2-amino-4-(trifluoromethyl)oxazole-5-carboxylate (A-1) (9.8 g) was suspended in acetonitrile (100 mL), and copper (II) bromide (11.8 g) and tert-butylnitrite (13.8 mL) were slowly added sequentially at 0 °C. The reaction mixture was slowly warmed from 0 °C to room temperature under nitrogen protection and stirred at this temperature for 4 hours. Upon completion of the reaction, the mixture was concentrated. The concentrated residue was suspended in EtOAc (200 mL), washed sequentially with 1N HCl (3 x 100 mL) and brine (1 x 100 mL), and the organic phase was dried over Na2SO4, filtered and concentrated. The crude product was purified by fast column chromatography (eluent: EtOAc/hexane) to afford ethyl 2-bromo-4-trifluoromethyl oxazole-5-carboxylate (A-2) as a colorless liquid (9.18 g, 73% yield).LCMS (ESI) [M + 1]+ 288.2.
References
[1] Patent: WO2010/59606, 2010, A2. Location in patent: Page/Page column 159
[2] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00321
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 23, p. 6410 - 6414
ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 2-BROMO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE Suppliers
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