(S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid
- Product Name
- (S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid
- CAS No.
- 1034190-08-3
- Chemical Name
- (S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid
- Synonyms
- ALZ-801;valiltramiprosate;ALZ-801;ALZ801;ALZ 801;Valiltramiprosate（ALZ-801）;Valiltramiprosate(ALZ-8010);NRZRFNYKMSAZBI-ZETCQYMHSA-N;(S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid;3-[(2S)-2-amino-3-methylbutanamido]propane-1-sulfonic acid;3-[[(2S)-2-Amino-3-methyl-1-oxobutyl]amino]-1-propanesulfonic acid;1-Propanesulfonic acid, 3-[[(2S)-2-amino-3-methyl-1-oxobutyl]amino]-
- CBNumber
- CB02650993
- Molecular Formula
- C8H18N2O4S
- Formula Weight
- 238.3
- MOL File
- 1034190-08-3.mol
(S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid Property
- Density
- 1.257±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Water:250.0(Max Conc. mg/mL);1049.1(Max Conc. mM)
- pka
- 1?+-.0.50(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water : 250 mg/mL (1049.10 mM; Need ultrasonic)
N-Bromosuccinimide Price
- Product number
- DC11301
- Product name
- ALZ-801
- Purity
- >98%
- Packaging
- 100mg
- Price
- $750
- Updated
- 2021/12/16
(S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid Chemical Properties,Usage,Production
Uses
ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound[1]. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease[2].
in vivo
ALZ-801 (oral administration; 172?mg/kg; single dose) exhibits mean AUCt values of 58,758 and? 5841 ng/ml.h in plasma and brain, respectively. The ALZ-801: Tramiprosate ratio in plasma and brain is 1.8 and 3.1, respectively in male CD-1 mice[1].
References
[1] John A. Hey, et al. Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain. CNS Drugs. 2018; 32(9): 849–861.
[2] Hey JA, et al. Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease. Clin Pharmacokinet. 2018 Mar;57(3):315-333. DOI:10.1007/s40262-017-0608-3
(S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid Preparation Products And Raw materials
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