AB 1010 Mesylate
- Product Name
- AB 1010 Mesylate
- CAS No.
- 1048007-93-7
- Chemical Name
- AB 1010 Mesylate
- Synonyms
- AB1010 Mesylate;AB-1010 Mesylate;AB 1010 Mesylate;Masivet Mesylate;Masitinib (Mesylate);Masitinib mesylate, 10 mM in DMSO;Masitinib mesylate (AB1010 mesylate;AB1010 MESYLATE;AB-1010 MESYLATE;AB 1010 MESYLATE;AB1010 MESYLATE; MASIVET MESYLATE; AB-1010 MESYLATE; AB 1010 MESYLATE;N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide methanesulfonate
- CBNumber
- CB02651152
- Molecular Formula
- C29H34N6O4S2
- Formula Weight
- 594.74806
- MOL File
- 1048007-93-7.mol
AB 1010 Mesylate Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 30 mg/mL (50.44 mM)
- form
- Powder
- color
- White to yellow
- InChIKey
- TXCWBWKVIZGWEQ-UHFFFAOYSA-N
- SMILES
- CS(O)(=O)=O.C(NC1=CC=C(C)C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)(=O)C1=CC=C(CN2CCN(C)CC2)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-1593
- Product name
- Masitinib(mesylate)
- Purity
- 99.76%
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3415AH
- Product name
- Masitinibmesylate
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-1593
- Product name
- Masitinib(mesylate)
- Purity
- 99.76%
- Packaging
- 50mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- CS-1593
- Product name
- Masitinib(mesylate)
- Purity
- 99.76%
- Packaging
- 100mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- INB0001354
- Product name
- 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-THIAZOL-2-YLAMINO)-PHENYL]-BENZAMIDE METHANESULFONATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $218.9
- Updated
- 2021/12/16
AB 1010 Mesylate Chemical Properties,Usage,Production
Uses
Masitinib is a novel tyrosine kinases inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, resectively.
Uses
Masitinib Mesylate can be used to treat sickle cell disease.
Synthesis
790299-79-5
75-75-2
1048007-93-7
Synthesis of N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide and methanesulfonic acid as 4-[(4-methyl-1-piperazinyl)methyl]-N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamidic acid The general procedure for the sulfonate is as follows: 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide (1.0 eq.) was dissolved in ethanol (4.5 v/v), and heated to 65-70°C to dissolve it completely. Under the condition of maintaining the same temperature, methanesulfonic acid (1.0 eq.) was slowly added. Upon completion of the reaction, the mixture was cooled to 25-30 °C and kept at this temperature for 6 hours to promote crystallization. The product was collected by filtration and dried in a vacuum disk dryer at 55-60°C. The yield of this step was 85-90% and the starting melting point of the product was 236°C.
in vivo
Masitinib inhibits tumour growth and increases the median survival time in Δ27-expressing Ba/F3 tumor models at 30 mg/kg, without cardiotoxicity or genotoxicity[1].
Masitinib (12.5 mg/kg/d, p.o.) increases overall TTP (time-to-tumor progression) compared with placebo in dogs[3].
References
[1] Patent: WO2008/98949, 2008, A2. Location in patent: Page/Page column 23
AB 1010 Mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from AB 1010 Mesylate manufacturers
- Product
- AB 1010 Mesylate 1048007-93-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25