Tivozanib

Product Name: Tivozanib
CAS No.: 682745-41-1
Chemical Name: Tivozanib
Synonyms: Tivozanib hydrochloride;Tivozanib hydrochloride hydrate;Tivozanib Hydrochloride Monohydrate;1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-urea monohydrochloride monohydrate
CBNumber: CB02651167
Molecular Formula: C22H22Cl2N4O6
Formula Weight: 509.34
MOL File: 682745-41-1.mol

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Tivozanib Property

storage temp.: 4°C, away from moisture and light
solubility: DMSO : 250 mg/mL (490.83 mM; Need ultrasonic)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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Tivozanib Chemical Properties,Usage,Production

Uses

Tivozanib also known as AV-951 is an orally bioavailable potent VEGFR-1, 2 and 3, c-Kit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM, respectively.

in vivo

Tivozanib hydrochloride hydrate (0.04-1 mg/kg, po for 14 days) exhibits antitumor efficacy against breast, colon, hepatic, lung, ovarian, pancreatic, and prostate cancer in athymic mice model^[1].
Tivozanib hydrochloride hydrate (0.2-1 mg/kg, po for 21 days) reversibly suppresses vascular permeability and angiogenesis in Calu-6 tumor bearing rats model^[1].
Tivozanib hydrochloride hydrate (5 mg/kg, po, single dose) reveals a AUC_inf of 44.5 μg·h/mL, C_max of 2823 ng/mL in athymic mice model^[1].

Animal Model:	Calu-6 tumor bearing athymic mice model^[1]
Dosage:	0.04-1 mg/kg/day
Administration:	p.o., for 14-21 days
Result:	Inhibited tumor growth, angiogenesis and vascular permeability.

IC 50

VEGFR-2: 6.5 nM (IC₅₀); VEGFR-3: 15 nM (IC₅₀); VEGFR-1: 30 nM (IC₅₀)

Tivozanib Preparation Products And Raw materials

Raw materials

Preparation Products

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Tivozanib Suppliers

China 28 United States 1 Global 29

Jinan Trio PharmaTech Co., Ltd.

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View Lastest Price from Tivozanib manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Tivozanib Hydrochloride Hydrate 682745-41-1
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-07-24

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Tivozanib Hydrochloride 682745-41-1
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-12-31

682745-41-1, TivozanibRelated Search:

1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea

N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-urea monohydrochloride monohydrate

Tivozanib hydrochloride

Tivozanib hydrochloride hydrate

Tivozanib Hydrochloride Monohydrate

682745-41-1

C22H22Cl2N4O6