diethyl 2,2-difluoropentanedioate

Product Name: diethyl 2,2-difluoropentanedioate
CAS No.: 428-97-7
Chemical Name: diethyl 2,2-difluoropentanedioate
Synonyms: diethyl 2,2-difluoropentanedioate;Pentanedioic acid, 2,2-difluoro-, 1,5-diethyl ester
CBNumber: CB02653707
Molecular Formula: C9H14F2O4
Formula Weight: 224.2
MOL File: 428-97-7.mol

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diethyl 2,2-difluoropentanedioate Property

Boiling point:: 127-128 °C(Press: 28 Torr)
Density: 1.149±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
InChI: InChI=1S/C9H14F2O4/c1-3-14-7(12)5-6-9(10,11)8(13)15-4-2/h3-6H2,1-2H3
InChIKey: YVPKMLFMDHSTKJ-UHFFFAOYSA-N
SMILES: C(OCC)(=O)C(F)(F)CCC(OCC)=O

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Safety

HS Code: 2918199890

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D680258
Product name: Diethyl2,2-Difluoropentanedioate
Packaging: 500mg
Price: $350
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2123-3-1Z
Product name: Diethyl 2,2-difluoropentanedioate
Packaging: 250mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2123-3-1Z
Product name: Diethyl 2,2-difluoropentanedioate
Packaging: 1g
Price: $150
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0368597
Product name: DIETHYL-2,2-DIFLUOROPENTANEDIOATE
Purity: 95.00%
Packaging: 5MG
Price: $505.08
Updated: 2021/12/16

Matrix Scientific

Product number: 126445
Product name: Diethyl2,2-difluoropentanedioate
Purity: >95%
Packaging: 1g
Price: $810
Updated: 2021/12/16

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diethyl 2,2-difluoropentanedioate Chemical Properties,Usage,Production

Synthesis

667-27-6

140-88-5

428-97-7

General procedure for the synthesis of diethyl 2,2-difluoroglutarate from ethyl bromodifluoroacetate and ethyl acrylate: copper powder (700 mg) and tetrahydrofuran (5.8 mL) were added to the reaction vessel and stirred at 50 °C. Ethyl acrylate (0.50 g), ethyl bromodifluoroacetate (2.53 g), TMEDA (0.29 g) and acetic acid (0.27 g) were then added sequentially. The reaction was terminated after 0.5 hrs. To the reaction mixture was added 10% aqueous ammonium chloride solution, filtered through a diatomaceous earth pad to remove the copper residue, and the filtrate was extracted with methyl tert-butyl ether to afford diethyl 2,2-difluoroglutarate (1.09 g, 97.4% yield). Alternatively, diethyl 2,2-difluoroglutarate (1.08 g, 96.4% yield) was obtained by following the same method as described above except that water (0.10 g) was used instead of acetic acid.

References

[1] Patent: CN104159884, 2016, B. Location in patent: Paragraph 0060; 0061; 0062; 0063; 0064
[2] Synthesis, 2012, vol. 44, # 20, p. 3165 - 3170,6
[3] Patent: WO2009/82134, 2009, A2. Location in patent: Page/Page column 41-42
[4] Patent: WO2012/30106, 2012, A2. Location in patent: Page/Page column 11
[5] Patent: US2013/165659, 2013, A1. Location in patent: Paragraph 0098; 0099; 0100

diethyl 2,2-difluoropentanedioate Preparation Products And Raw materials

Raw materials

Preparation Products

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diethyl 2,2-difluoropentanedioate Suppliers

Canada 1 China 36 India 2 United Kingdom 1 United States 4 Global 44

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View Lastest Price from diethyl 2,2-difluoropentanedioate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: diethyl 2,2-difluoropentanedioate 428-97-7
Price: US $15.00-5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000KG
Release date: 2024-07-16

Shaanxi Dideu Medichem Co. Ltd

Product: diethyl 2,2-difluoropentanedioate 428-97-7
Price: US $225.00-227.00/G
Min. Order: 25G
Purity: 99%
Supply Ability: 1000G
Release date: 2024-05-13

428-97-7, diethyl 2,2-difluoropentanedioateRelated Search:

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diethyl 2,2-difluoropentanedioate

Pentanedioic acid, 2,2-difluoro-, 1,5-diethyl ester

428-97-7

C9H14F2O4