ChemicalBook > CAS DataBase List > (S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid
(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid
- Product Name
- (S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid
- CAS No.
- 1215197-37-7
- Chemical Name
- (S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid
- Synonyms
- PF-04991532;PF 04991532;PF 04991532,PF04991532;PF-04991532 >=98% (HPLC);(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid;6-[[(2S)-3-Cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 6-[[(2S)-3-cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]-
- CBNumber
- CB02657114
- Molecular Formula
- C18H19F3N4O3
- Formula Weight
- 396.36
- MOL File
- 1215197-37-7.mol
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(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid Property
- Boiling point:
- 646.5±55.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble20mg/mL, clear
- pka
- 3.55±0.10(Predicted)
- form
- powder
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- PZ0223
- Product name
- PF-04991532
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- PZ0223
- Product name
- PF-04991532
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $380
- Updated
- 2024/03/01
Tocris
- Product number
- 6345
- Product name
- PF04991532
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $65
- Updated
- 2021/12/16
Tocris
- Product number
- 6345
- Product name
- PF04991532
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $252
- Updated
- 2021/12/16
TRC
- Product number
- P294123
- Product name
- PF04991532
- Packaging
- 25mg
- Price
- $310
- Updated
- 2021/12/16
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(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid Chemical Properties,Usage,Production
Uses
PF 04991532 is a useful research chemical used as a hepatoselective glucokinase activator for treating type 2 diabetes mellitus.
Biological Activity
PF-04991532 is a potent and hepatoselective glucokinase activator th at reduces mean daily glucose (MDG), fasting plasma glucose (FPG) and glucose excursion in humans.
in vivo
A single dose of PF-04991532 increases the glucose infusion rate in order to maintain hyperglycemia. Despite the elevations in plasma triglycerides, surprisingly, hepatic triglycerides in rats dosed with 19 days of PF-04991532 are identical to vehicle treated GK rats. In an additional cohort treated for 28 days, identical hepatic lipid concentrations are observed between vehicle and rats dosed with PF-04991532 (Vehicle: 9.89±0.31; PF-04991532 100 mg/kg: 9.91±0.31). In rats treated with PF-04991532, there is increased expression of lipogenic gene expression such as acetyl-CoA carboxylase (ACC), ATP citrate lyase (ACLY), and fatty acid synthase (FAS)[1].
(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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