(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid
- Product Name
- (S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid
- CAS No.
- 1215197-37-7
- Chemical Name
- (S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid
- Synonyms
- PF-04991532;PF 04991532;PF 04991532,PF04991532;PF-04991532 >=98% (HPLC);(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid;6-[[(2S)-3-Cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 6-[[(2S)-3-cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]-
- CBNumber
- CB02657114
- Molecular Formula
- C18H19F3N4O3
- Formula Weight
- 396.36
- MOL File
- 1215197-37-7.mol
(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid Property
- Boiling point:
- 646.5±55.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble20mg/mL, clear
- pka
- 3.55±0.10(Predicted)
- form
- powder
- color
- white to beige
- InChI
- 1S/C18H19F3N4O3/c19-18(20,21)14-9-25(10-23-14)13(7-11-3-1-2-4-11)16(26)24-15-6-5-12(8-22-15)17(27)28/h5-6,8-11,13H,1-4,7H2,(H,27,28)(H,22,24,26)/t13-/m0/s1
- InChIKey
- GKMLFBRLRVQVJO-ZDUSSCGKSA-N
- SMILES
- FC(F)(F)c1nc[n](c1)[C@@H](CC3CCCC3)C(=O)Nc2ncc(cc2)C(=O)O
Safety
- WGK Germany
- 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PZ0223
- Product name
- PF-04991532
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- PZ0223
- Product name
- PF-04991532
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $380
- Updated
- 2024/03/01
- Product number
- 6345
- Product name
- PF04991532
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 6345
- Product name
- PF04991532
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $252
- Updated
- 2021/12/16
- Product number
- P294123
- Product name
- PF04991532
- Packaging
- 25mg
- Price
- $310
- Updated
- 2021/12/16
(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid Chemical Properties,Usage,Production
Uses
PF 04991532 is a useful research chemical used as a hepatoselective glucokinase activator for treating type 2 diabetes mellitus.
Biological Activity
PF-04991532 is a potent and hepatoselective glucokinase activator th at reduces mean daily glucose (MDG), fasting plasma glucose (FPG) and glucose excursion in humans.
in vivo
A single dose of PF-04991532 increases the glucose infusion rate in order to maintain hyperglycemia. Despite the elevations in plasma triglycerides, surprisingly, hepatic triglycerides in rats dosed with 19 days of PF-04991532 are identical to vehicle treated GK rats. In an additional cohort treated for 28 days, identical hepatic lipid concentrations are observed between vehicle and rats dosed with PF-04991532 (Vehicle: 9.89±0.31; PF-04991532 100 mg/kg: 9.91±0.31). In rats treated with PF-04991532, there is increased expression of lipogenic gene expression such as acetyl-CoA carboxylase (ACC), ATP citrate lyase (ACLY), and fatty acid synthase (FAS)[1].
(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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