5-BroMo-3-Methylpyrazin-2-ol
- Product Name
- 5-BroMo-3-Methylpyrazin-2-ol
- CAS No.
- 100047-56-1
- Chemical Name
- 5-BroMo-3-Methylpyrazin-2-ol
- Synonyms
- 5-BroMo-3-Methylpyrazin-2-ol;5-BroMo-3-Methylpyrazin-2-one;5-bromo-3-methyl-1H-pyrazin-2-one;5-Bromo-3-methyl-2(1H)-pyrazinone;2(1H)-Pyrazinone, 5-bromo-3-methyl;5-BroMo-2-hydroxy-3-Methyl pyrazine
- CBNumber
- CB02661100
- Molecular Formula
- C5H5BrN2O
- Formula Weight
- 189.01
- MOL File
- 100047-56-1.mol
5-BroMo-3-Methylpyrazin-2-ol Property
- Density
- 1.84±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 10.05±0.60(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- FB145035
- Product name
- 5-Bromo-2-hydroxy-3-methyl pyrazine
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB145035
- Product name
- 5-Bromo-2-hydroxy-3-methyl pyrazine
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 1452CZ
- Product name
- 5-Bromo-3-methylpyrazin-2-ol
- Packaging
- 1g
- Price
- $188
- Updated
- 2021/12/16
- Product number
- FB145035
- Product name
- 5-Bromo-2-hydroxy-3-methyl pyrazine
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB145035
- Product name
- 5-Bromo-2-hydroxy-3-methyl pyrazine
- Packaging
- 250mg
- Price
- $300
- Updated
- 2021/12/16
5-BroMo-3-Methylpyrazin-2-ol Chemical Properties,Usage,Production
Synthesis
19838-07-4
100047-56-1
The general procedure for the synthesis of 2-hydroxy-3-methyl-5-bromopyrazine from 2-hydroxy-3-methylpyrazine was as follows: to a solution of 3-methylpyrazin-2-ol (1.5 g, 13.62 mmol) in anhydrous N,N-dimethylformamide (DMF, 20 mL) was added batchwise at 0 °C N-bromosuccinimide (NBS, 2.67 g, 14.98 mmol). The reaction mixture was slowly warmed to room temperature and stirred overnight. Upon completion of the reaction, the mixture was poured into ice water and extracted with a solvent mixture of isopropanol (IPA)/dichloromethane (DCM, 1/5, v/v). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with 80% ethyl acetate/hexane (v/v) as eluent to afford 2-hydroxy-3-methyl-5-bromopyrazine as white solid (1.97 g, 10.42 mmol, 77% yield). The product was analyzed by mass spectrometry (LCMS) with measured m/z = 189.0 [M+H]+ (calculated exact mass of C5H5BrN2O: 188.0).1H NMR (400 MHz, DMSO-d6) δppm: 2.27 (d, J = 0.5 Hz, 3H), 7.73 (s, 1H), 12.3 (s, 1H).
References
[1] Patent: WO2011/127051, 2011, A1. Location in patent: Page/Page column 205
5-BroMo-3-Methylpyrazin-2-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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