Methyl 4-broMo-5-chlorothiophene-2-carboxylate
- Product Name
- Methyl 4-broMo-5-chlorothiophene-2-carboxylate
- CAS No.
- 1047630-72-7
- Chemical Name
- Methyl 4-broMo-5-chlorothiophene-2-carboxylate
- Synonyms
- 4-broMo-5-chlorothiophene-2-carboxylate;methyl 4-bromo-5-chloro-2-thiophenecarboxyl;methyl 4-bromo-5-chloro-2-thiophenecarboxylate;Methyl 4-broMo-5-chlorothiophene-2-carboxylate;4-Bromo-5-chloro-2-thiophenecarboxylic acid methyl ester;2-Thiophenecarboxylic acid, 4-bromo-5-chloro-, methyl ester
- CBNumber
- CB02664383
- Molecular Formula
- C6H4BrClO2S
- Formula Weight
- 255.52
- MOL File
- 1047630-72-7.mol
Methyl 4-broMo-5-chlorothiophene-2-carboxylate Property
- Boiling point:
- 293.9±35.0 °C(Predicted)
- Density
- 1.762±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M296673
- Product name
- Methyl4-Bromo-5-chlorothiophene-2-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-M2942
- Product name
- 2-Thiophenecarboxylicacid,4-bromo-5-chloro-,methylester
- Packaging
- 10g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- CS-M2942
- Product name
- 2-Thiophenecarboxylicacid,4-bromo-5-chloro-,methylester
- Packaging
- 25g
- Price
- $209
- Updated
- 2021/12/16
- Product number
- CS-M2942
- Product name
- 2-Thiophenecarboxylicacid,4-bromo-5-chloro-,methylester
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- A115306
- Product name
- Methyl4-bromo-5-chlorothiophene-2-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
Methyl 4-broMo-5-chlorothiophene-2-carboxylate Chemical Properties,Usage,Production
Synthesis
35475-03-7
1047630-72-7
General procedure for the synthesis of methyl 5-chloro-4-bromothiophene-2-carboxylate from methyl 5-chlorothiophene-2-carboxylate: To a 1 L round bottom flask was added aluminum chloride (11.32 g, 85 mmol) and methyl 5-chlorothiophene-2-carboxylate (10 g, 56.6 mmol) dissolved in chloroform (250 mL). Bromine (4.08 mL, 79 mmol) was added slowly and dropwise over 10 min. The reaction mixture was stirred at 25 °C for 6 h. The light orange reaction solution was washed with saturated sodium bicarbonate solution. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by silica gel column chromatography [n-hexane/ethyl acetate, 9:1] to give the target product (12 g, 80% yield) as a white solid.LC-MS (ESI) m/z 256 ([M+H]+).
References
[1] Patent: WO2008/98104, 2008, A1. Location in patent: Page/Page column 188
[2] Drugs of the Future, 2014, vol. 39, # 8, p. 541 - 546
Methyl 4-broMo-5-chlorothiophene-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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