(S)-4-Boc-broMoMethylMorpholine
- Product Name
- (S)-4-Boc-broMoMethylMorpholine
- CAS No.
- 919286-71-8
- Chemical Name
- (S)-4-Boc-broMoMethylMorpholine
- Synonyms
- (S)-4-Boc-broMoMethylMorpholine;(S)-4-Boc-2-broMoMethylMorpholine;N-Boc-(2S)-(bromomethyl)morpholine;(2S)-4-Boc-2-(bromomethyl)-morpholine;(S)-tert-butyl 2-(broMoMethyl)Morpholine-4-carboxylate;tert-butyl (S)-2-(bromomethyl)morpholine-4-carboxylate;tert-butyl (2S)-2-(bromomethyl)morpholine-4-carboxylate;(2S)-2-(Bromomethyl)-4-morpholinecarboxylic acid 1,1-dimethylethyl ester;4-Morpholinecarboxylic acid, 2-(bromomethyl)-, 1,1-dimethylethyl ester, (2S)-
- CBNumber
- CB02664404
- Molecular Formula
- C10H18BrNO3
- Formula Weight
- 280.16
- MOL File
- 919286-71-8.mol
(S)-4-Boc-broMoMethylMorpholine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
N-Bromosuccinimide Price
- Product number
- 5531AC
- Product name
- (S)-tert-Butyl2-(bromomethyl)morpholine-4-carboxylate
- Packaging
- 250mg
- Price
- $162
- Updated
- 2021/12/16
- Product number
- CCH0033495
- Product name
- (S)-TERT-BUTYL-2-(BROMOMETHYL)MORPHOLINE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.14
- Updated
- 2021/12/16
- Product number
- CCH0033495
- Product name
- (S)-TERT-BUTYL-2-(BROMOMETHYL)MORPHOLINE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $525
- Updated
- 2021/12/16
- Product number
- 095245
- Product name
- (S)-tert-Butyl 2-(bromomethyl)-morpholine-4-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $643
- Updated
- 2021/12/16
- Product number
- 095245
- Product name
- (S)-tert-Butyl 2-(bromomethyl)-morpholine-4-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1428
- Updated
- 2021/12/16
(S)-4-Boc-broMoMethylMorpholine Chemical Properties,Usage,Production
Synthesis
135065-76-8
919286-71-8
The general procedure for the synthesis of tert-butyl (S)-2-(bromomethyl)morpholine-4-carboxylate from (S)-N-Boc-2-hydroxymethylmorpholine was as follows: (S)-N-Boc-2-hydroxymethylmorpholine (6.9 g, 0.032 mol) and carbon tetrabromide (15.8 g, 0.048 mol) were dissolved in dichloromethane (100 mL) and cooled in an ice bath to 0°C. A solution of triphenylphosphine (12.2 g, 0.046 mol) in dichloromethane (100 mL) was added slowly and dropwise over 30 minutes. The reaction temperature was maintained at 0 °C with stirring for 1 h. The reaction was gradually warmed to room temperature and stirring was continued overnight. Upon completion of the reaction, the reaction solution was concentrated to 1/2 of the original volume by distillation under reduced pressure, followed by filtration of the concentrate through a pad of silica gel and elution of the target product with a hexane solution of 15% ethyl acetate as eluent. The filtrate containing the product was collected and the solvent was removed by concentration under reduced pressure to afford tert-butyl (S)-2-(bromomethyl)morpholine-4-carboxylate as a colorless oil (8 g, 90% yield). Mass spectrometry (electrospray ionization, positive ion mode) showed m/e 281 [M + H]+.
References
[1] Patent: WO2008/121685, 2008, A1. Location in patent: Page/Page column 44
[2] Patent: WO2007/6715, 2007, A1. Location in patent: Page/Page column 34; 35-36
[3] Patent: WO2007/6714, 2007, A1. Location in patent: Page/Page column 122
[4] Patent: WO2007/58850, 2007, A2. Location in patent: Page/Page column 50
(S)-4-Boc-broMoMethylMorpholine Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-4-Boc-broMoMethylMorpholine Suppliers
- Tel
- --
- Fax
- --
- info@synthonix.com
- Country
- United States
- ProdList
- 6872
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
- 69
- Tel
- --
- Fax
- --
- sales@matrixscientific.com
- Country
- United States
- ProdList
- 6632
- Advantage
- 80