4-Ethynyl-L-phenylalanine HCl
- Product Name
- 4-Ethynyl-L-phenylalanine HCl
- CAS No.
- 278605-15-5
- Chemical Name
- 4-Ethynyl-L-phenylalanine HCl
- Synonyms
- 4-Ethynylphenylalanine;4-Ethynyl-L-phenylalanine;L-Phenylalanine, 4-ethynyl-;4-Ethynyl-L-phenylalanine HCl;p-Ethynylphenylalanine, 10 mM in DMSO;pEthynylphenylalanine,p Ethynylphenylalanine;(S)-2-Amino-3-(4-ethynylphenyl)propanoic acid;(2S)-2-amino-3-(4-ethynylphenyl)propanoic acid
- CBNumber
- CB02665148
- Molecular Formula
- C11H11NO2
- Formula Weight
- 189.21
- MOL File
- 278605-15-5.mol
4-Ethynyl-L-phenylalanine HCl Property
- Boiling point:
- 343.2±37.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 2.22 mg/mL (11.73 mM)
- form
- Solid
- pka
- 2.18±0.10(Predicted)
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0100675
- Product name
- p-Ethynylphenylalanine
- Purity
- 98.25%
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- AC-1881
- Product name
- 4-Ethynyl-L-phenylalanineHCl
- Purity
- 97%
- Packaging
- 1g
- Price
- $495
- Updated
- 2021/12/16
4-Ethynyl-L-phenylalanine HCl Chemical Properties,Usage,Production
Uses
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase[1].
| Animal Model: | Male Sprague-Dawley rats (200 g)[1] |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |
References
[1] Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73. DOI:10.1046/j.1471-4159.2000.0742067.x
4-Ethynyl-L-phenylalanine HCl Preparation Products And Raw materials
Raw materials
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