4-Ethynyl-L-phenylalanine HCl

Product Name: 4-Ethynyl-L-phenylalanine HCl
CAS No.: 278605-15-5
Chemical Name: 4-Ethynyl-L-phenylalanine HCl
Synonyms: 4-Ethynylphenylalanine;4-Ethynyl-L-phenylalanine;L-Phenylalanine, 4-ethynyl-;4-Ethynyl-L-phenylalanine HCl;p-Ethynylphenylalanine, 10 mM in DMSO;pEthynylphenylalanine,p Ethynylphenylalanine;(S)-2-Amino-3-(4-ethynylphenyl)propanoic acid;(2S)-2-amino-3-(4-ethynylphenyl)propanoic acid
CBNumber: CB02665148
Molecular Formula: C11H11NO2
Formula Weight: 189.21
MOL File: 278605-15-5.mol

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4-Ethynyl-L-phenylalanine HCl Property

Boiling point:: 343.2±37.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 2.22 mg/mL (11.73 mM)
form: Solid
pka: 2.18±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0100675
Product name: p-Ethynylphenylalanine
Purity: 99.93%
Packaging: 50mg
Price: $108
Updated: 2026/06/04

ChemScene

Product number: CS-0100675
Product name: p-Ethynylphenylalanine
Purity: 99.93%
Packaging: 50mg
Price: $108
Updated: 2026/06/04

aablocks

Product number: AA01G8GJ
Product name: 4-Ethynyl-L-phenylalanine
Packaging: 10mg
Price: $48
Updated: 2026/05/30

aablocks

Product number: AA01G8GJ
Product name: 4-Ethynyl-L-phenylalanine
Packaging: 25mg
Price: $64
Updated: 2026/05/30

aablocks

Product number: AA01G8GJ
Product name: 4-Ethynyl-L-phenylalanine
Packaging: 50mg
Price: $84
Updated: 2026/05/30

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4-Ethynyl-L-phenylalanine HCl Chemical Properties,Usage,Production

Uses

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vivo

p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue^[1].
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase^[1].

Animal Model:	Male Sprague-Dawley rats (200 g)^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection
Result:	Decreased in 5-HT and 5-HIAA levels in the rat midbrain.

References

[1] Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73. DOI:10.1046/j.1471-4159.2000.0742067.x

4-Ethynyl-L-phenylalanine HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Ethynyl-L-phenylalanine HCl Suppliers

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278605-15-5, 4-Ethynyl-L-phenylalanine HClRelated Search:

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(S)-2-Amino-3-(4-ethynylphenyl)propanoic acid

p-Ethynylphenylalanine, 10 mM in DMSO

4-Ethynyl-L-phenylalanine

4-Ethynylphenylalanine

278605-15-5