ChemicalBook > CAS DataBase List > AT-7519 trifluoroacetate

AT-7519 trifluoroacetate

Product Name
AT-7519 trifluoroacetate
CAS No.
1431697-85-6
Chemical Name
AT-7519 trifluoroacetate
Synonyms
AT7519 TFA;AT7519 TFA,AT-7519 TFA;AT 7519 trifluoroacetate;AT-7519 trifluoroacetate;AT7519 (trifluoroacetate);AT 7519 TRIFLUOROACETATE;AT-7519 TRIFLUOROACETATE;4-[(2,6-Dichlorobenzoyl)amino]-N-4-piperidinyl-1H-pyrazole-3-carboxamide 2,2,2-trifluoroacetate
CBNumber
CB02666589
Molecular Formula
C18H18Cl2F3N5O4
Formula Weight
496.2678296
MOL File
1431697-85-6.mol
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AT-7519 trifluoroacetate Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
color 
White to gray
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-1167
Product name
AT7519trifluoroacetate
Purity
98.16%
Packaging
50mg
Price
$190
Updated
2021/12/16
ApexBio Technology
Product number
A3198
Product name
AT7519trifluoroacetate
Packaging
10mg
Price
$213
Updated
2021/12/16
ChemScene
Product number
CS-1167
Product name
AT7519trifluoroacetate
Purity
98.16%
Packaging
100mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-1167
Product name
AT7519trifluoroacetate
Purity
98.16%
Packaging
5mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-1167
Product name
AT7519trifluoroacetate
Purity
98.16%
Packaging
10mg
Price
$90
Updated
2021/12/16
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AT-7519 trifluoroacetate Chemical Properties,Usage,Production

Uses

AT7519 (AT7519M) TFA as a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.

in vivo

AT7519 TFA inhibits tumor growth in a human MM xenograft mouse model[1]. AT7519 (4.6 and 9.1 mg/kg/dose) inhibits the growth of early-stage HCT116 tumor xenografts. AT7519 (10 mg/kg, i.p.) TFA also inhibits the target CDKs in HCT116 tumor-bearing BALB/c nude mice[2].

IC 50

CDK9/Cyclin T: 10 nM (IC50); CDK5/p35: 13 nM (IC50); cdk2/cyclin A: 47 nM (IC50); Cdk4/cyclin D1: 100 nM (IC50); cdk6/cyclin D3: 170 nM (IC50); Cdk1/cyclin B: 210 nM (IC50); CDK7/Cyclin H/MAT1: 2400 nM (IC50); GSK3β: 89 nM (IC50)

References

[1] Santo L, et al. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition. Oncogene. 2010 Apr 22;29(16):2325-36. DOI:10.1038/onc.2009.510
[2] Squires MS, et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. DOI:10.1158/1535-7163.MCT-08-0890
[3] Squires MS, et al. AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples. Mol Cancer Ther. 2010 Apr;9(4):920-8. DOI:10.1158/1535-7163.MCT-09-1071

AT-7519 trifluoroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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AT-7519 trifluoroacetate Suppliers

China 27 United States 9 Global 36
Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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sales@boylechem.com
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China
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BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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AdooQ Bioscience CHINA
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025-58849295 18951903616;
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025-68650336
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SPIRO PHARMA
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BOC Sciences
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16314854226
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Guangzhou QiYun Biotechnology Co., Ltd.
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020-61288194 61288195
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020-61288700
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505721671@qq.com
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China
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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klq@cw-bio.com
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China
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1431697-85-6, AT-7519 trifluoroacetateRelated Search:


  • AT 7519 trifluoroacetate
  • AT7519 (trifluoroacetate)
  • AT-7519 trifluoroacetate
  • 4-[(2,6-Dichlorobenzoyl)amino]-N-4-piperidinyl-1H-pyrazole-3-carboxamide 2,2,2-trifluoroacetate
  • AT 7519 TRIFLUOROACETATE;AT-7519 TRIFLUOROACETATE
  • AT7519 TFA
  • AT7519 TFA,AT-7519 TFA
  • 1431697-85-6
  • C18H18Cl2F3N5O4
  • C16H17Cl2N5O2C2HF3O2