ChemicalBook > CAS DataBase List > BMS 354825 hydrochloride

BMS 354825 hydrochloride

Product Name: BMS 354825 hydrochloride
CAS No.: 854001-07-3
Chemical Name: BMS 354825 hydrochloride
Synonyms: BMS-354825 HCl;Sprycel hydrochloride;BMS354825 hydrochloride;BMS-354825 hydrochloride;BMS 354825 hydrochloride;Dasatinib (hydrochloride);Dasatinib hydrochloride, 10 mM in DMSO;Abmole M5552-500mg Dasatinib HCl 854001-07-3;Dasatinib hydrochloride (BMS-354825 hydrochloride;BMS-354825 HYDROCHLORIDE;BMS354825 HYDROCHLORIDE;BMS 354825 HYDROCHLORIDE
CBNumber: CB02666615
Molecular Formula: C22H27Cl2N7O2S
Formula Weight: 524.47
MOL File: 854001-07-3.mol

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BMS 354825 hydrochloride Property

Melting point:: 279-280 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO : 15 mg/mL (28.60 mM; Need ultrasonic and warming)H2O : 10 mg/mL (19.07 mM; Need ultrasonic)
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3351
Product name: Dasatinibhydrochloride
Packaging: 100mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-1585
Product name: Dasatinib(hydrochloride)
Purity: 98.86%
Packaging: 100mg
Price: $66
Updated: 2021/12/16

ChemScene

Product number: CS-1585
Product name: Dasatinib(hydrochloride)
Purity: 98.86%
Packaging: 200mg
Price: $78
Updated: 2021/12/16

ApexBio Technology

Product number: A3351
Product name: Dasatinibhydrochloride
Packaging: 500mg
Price: $95
Updated: 2021/12/16

ChemScene

Product number: CS-1585
Product name: Dasatinib(hydrochloride)
Purity: 98.86%
Packaging: 500mg
Price: $118
Updated: 2021/12/16

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BMS 354825 hydrochloride Chemical Properties,Usage,Production

Uses

Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively[1]. Dasatinib hydrochloride also induces apoptosis and autophagy.

in vivo

Dasatinib (5 mg/kg and 50 mg/kg, qd×10d, 5 on-2 off) possesses potent antitumor activity and a high safety margin in a K562 xenograft model of chronic myelogenous leukemia (CML), demonstrating complete tumor regressions and low toxicity at multiple dose levels^[1].
? Dasatinib (10 mg/kg) has a pharmacokinetic profile appropriate for continued advancement into in vivo efficacy studies. Dasatinib (10 mg/kg) demonstrates favorable half-lives (t_1/2s) of 3.3 and 3.1 h for i.v. and oral, respectively. The oral bioavailability (F_po) in this study is 27%^[1].

Animal Model:	Nude mice bearing K562 xenografts
Dosage:	5 mg/kg and 50 mg/kg
Administration:	Oral administration on a 5 day on and 2 day off schedule.
Result:	Showed partial tumor regressions after one treatment cycle and complete disappearance of the tumor mass by the end of drug treatment. No toxicity (animal deaths, lack of weight gain) was observed.

Animal Model:	Sprague-Dawley Rats
Dosage:	10 mg/kg (Pharmacokinetic Analysis)
Administration:	Oral and i.v.
Result:	C_max of 13.2 and 0.5 μM for i.v. and oral, respectively.

IC 50

Bcr-Abl: 1.0 nM (IC₅₀); Src: 0.5 nM (IC₅₀); lck: 0.4 nM (IC₅₀); Yes: 0.5 nM (IC₅₀); c-kit: 5.0 nM (IC₅₀); PDGFRβ: 28 nM (IC₅₀); p38: 100 nM (IC₅₀); Her1: 180 nM (IC₅₀); Her2: 710 nM (IC₅₀); FGFR-1: 880 nM (IC₅₀); MEK: 1700 nM (IC₅₀)

References

[1] Lombardo LJ, et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47(27):6658-61. DOI:10.1021/jm049486a

BMS 354825 hydrochloride Preparation Products And Raw materials

Raw materials

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854001-07-3, BMS 354825 hydrochlorideRelated Search:

AZD-9291 Ceritinib (LDK378) LOXO-101 Cabozantinib Lapatinib Erlotinib Dasatinib

BMS 354825 hydrochloride

BMS354825 hydrochloride

BMS-354825 hydrochloride

Dasatinib (hydrochloride)

Sprycel hydrochloride

Dasatinib hydrochloride (BMS-354825 hydrochloride

BMS-354825 HYDROCHLORIDE;BMS354825 HYDROCHLORIDE;BMS 354825 HYDROCHLORIDE

BMS-354825 HYDROCHLORIDE; SPRYCEL HYDROCHLORIDE; BMS354825 HYDROCHLORIDE; BMS 354825 HYDROCHLORIDE

BMS-354825 HCl

N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide hydrochloride

Dasatinib hydrochloride, 10 mM in DMSO

Abmole M5552-500mg Dasatinib HCl 854001-07-3

854001-07-3