ChemicalBook > CAS DataBase List > SAR-407899

SAR-407899

Product Name: SAR-407899
CAS No.: 923262-96-8
Chemical Name: SAR-407899
Synonyms: CS-2364;SAR407899;SAR 407899;SAR-407899;SAR407899 HCl;SAR 407899;SAR407899;SAR407899 (hydrochloride);SAR407899 hydrochloride ，E2385;SAR-407899 （SAR407899，SAR 407899）;SAR407899 hydrochloride, 10 mM in DMSO
CBNumber: CB02666958
Molecular Formula: C14H17ClN2O2
Formula Weight: 280.74998
MOL File: 923262-96-8.mol

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SAR-407899 Property

storage temp.: Store at -20°C
solubility: H2O : 50 mg/mL (178.09 mM; Need ultrasonic)DMSO : 25 mg/mL (89.05 mM; Need ultrasonic)
form: Powder
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3569
Product name: SAR407899hydrochloride
Purity: >98.0%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ApexBio Technology

Product number: B4909
Product name: SAR407899hydrochloride
Packaging: 2mg
Price: $95
Updated: 2021/12/16

ChemScene

Product number: CS-3569
Product name: SAR407899hydrochloride
Purity: >98.0%
Packaging: 10mg
Price: $100
Updated: 2021/12/16

ApexBio Technology

Product number: B4909
Product name: SAR407899hydrochloride
Packaging: 5mg
Price: $156
Updated: 2021/12/16

ApexBio Technology

Product number: B4909
Product name: SAR407899hydrochloride
Packaging: 10mg
Price: $268
Updated: 2021/12/16

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SAR-407899 Chemical Properties,Usage,Production

Uses

SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

in vivo

SAR407899 (3 mg/kg, i.v.) inhibits ROCK-mediated phosphorylation of MYPT^T696 in thoracic aorta of spontaneously hypertensive rats (SHRs). SAR407899 (0.01-0.30 mg/kg, i.v.) efficiently reduces pressor responses to vasoconstrictor agents in rats. SAR407899 (1, 3, 10, and 30 mg/kg, p.o.) dose dependently lowers blood pressure in hypertensive SHRs^[1]. SAR407899 (1-3 mg/kg, i.v. or 3, 10 mg/kg, p.o.) increases the length of the penis in healthy rabbits. SAR407899 (3-10 mg/kg, p.o.) also dose-dependently increases penile length in diabetic rabbits^[2].

IC 50

ROCK-2: 102 nM (IC₅₀); ROCK-1: 276 nM (IC₅₀)

References

[1] L?hn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83. DOI:10.1161/HYPERTENSIONAHA.109.134353
[2] Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59. DOI:10.1186/1479-5876-10-59
[3] Chen W, et al. Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts.Transpl Immunol. 2018 Jun 6. pii: S0966-3274(18)30029-7. DOI:10.1016/j.trim.2018.06.002

SAR-407899 Preparation Products And Raw materials

Raw materials

Preparation Products

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SAR-407899 Suppliers

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View Lastest Price from SAR-407899 manufacturers

Career Henan Chemical Co

Product: SAR-407899 923262-96-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100KG
Release date: 2020-03-13

923262-96-8, SAR-407899Related Search:

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CS-2364

SAR-407899 （SAR407899，SAR 407899）

SAR 407899;SAR407899

SAR-407899,Rho-associated protein kinase,ROK,Rho-associated kinase,SAR 407899,SAR-407899 hydrochloride,Rho-kinase,Inhibitor,inhibit,SAR407899 hydrochloride,ROCK,SAR407899

SAR407899 hydrochloride, 10 mM in DMSO

SAR407899 hydrochloride ，E2385

923262-96-8

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