ChemicalBook > CAS DataBase List > SAR-407899

SAR-407899

Product Name
SAR-407899
CAS No.
923262-96-8
Chemical Name
SAR-407899
Synonyms
CS-2364;SAR407899;SAR 407899;SAR-407899;SAR407899 HCl;SAR 407899;SAR407899;SAR407899 (hydrochloride);SAR407899 hydrochloride ，E2385;SAR-407899 （SAR407899，SAR 407899）;SAR407899 hydrochloride, 10 mM in DMSO
CBNumber
CB02666958
Molecular Formula
C14H17ClN2O2
Formula Weight
280.74998
MOL File
923262-96-8.mol
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SAR-407899 Property

storage temp. 
Store at -20°C
solubility 
H2O : 50 mg/mL (178.09 mM; Need ultrasonic)DMSO : 25 mg/mL (89.05 mM; Need ultrasonic)
form 
Powder
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3569
Product name
SAR407899hydrochloride
Purity
>98.0%
Packaging
5mg
Price
$60
Updated
2021/12/16
ApexBio Technology
Product number
B4909
Product name
SAR407899hydrochloride
Packaging
2mg
Price
$95
Updated
2021/12/16
ChemScene
Product number
CS-3569
Product name
SAR407899hydrochloride
Purity
>98.0%
Packaging
10mg
Price
$100
Updated
2021/12/16
ApexBio Technology
Product number
B4909
Product name
SAR407899hydrochloride
Packaging
5mg
Price
$156
Updated
2021/12/16
ApexBio Technology
Product number
B4909
Product name
SAR407899hydrochloride
Packaging
10mg
Price
$268
Updated
2021/12/16
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SAR-407899 Chemical Properties,Usage,Production

Uses

SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

in vivo

SAR407899 (3 mg/kg, i.v.) inhibits ROCK-mediated phosphorylation of MYPTT696 in thoracic aorta of spontaneously hypertensive rats (SHRs). SAR407899 (0.01-0.30 mg/kg, i.v.) efficiently reduces pressor responses to vasoconstrictor agents in rats. SAR407899 (1, 3, 10, and 30 mg/kg, p.o.) dose dependently lowers blood pressure in hypertensive SHRs[1]. SAR407899 (1-3 mg/kg, i.v. or 3, 10 mg/kg, p.o.) increases the length of the penis in healthy rabbits. SAR407899 (3-10 mg/kg, p.o.) also dose-dependently increases penile length in diabetic rabbits[2].

IC 50

ROCK-2: 102 nM (IC50); ROCK-1: 276 nM (IC50)

References

[1] L?hn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83. DOI:10.1161/HYPERTENSIONAHA.109.134353
[2] Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59. DOI:10.1186/1479-5876-10-59
[3] Chen W, et al. Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts.Transpl Immunol. 2018 Jun 6. pii: S0966-3274(18)30029-7. DOI:10.1016/j.trim.2018.06.002

SAR-407899 Preparation Products And Raw materials

Raw materials

Preparation Products

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SAR-407899 Suppliers

China 69 United States 8 Global 77
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
ApexBio Technology
Tel
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Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
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65
Matrix Scientific
Tel
--
Fax
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Email
sales@matrixscientific.com
Country
United States
ProdList
6632
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View Lastest Price from SAR-407899 manufacturers

Career Henan Chemical Co
Product
SAR-407899 923262-96-8
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100KG
Release date
2020-03-13

923262-96-8, SAR-407899Related Search:


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  • API