GSK2110183B

ChemicalBook > CAS DataBase List > GSK2110183B

Product Name: GSK2110183B
CAS No.: 1047645-82-8
Chemical Name: GSK2110183B
Synonyms: GSK2110183B;GSK 2110183B;GSK-2110183B;Afuresertib HCl;GSK2110183 hydrochloride;GSK-2110183 hydrochloride;GSK 2110183 hydrochloride;Afuresertib (hydrochloride);Afuresertib HCl (GSK2110183);Afuresertib hydrochloride GSK2110183
CBNumber: CB02667591
Molecular Formula: C18H18Cl3FN4OS
Formula Weight: 463.78
MOL File: 1047645-82-8.mol

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GSK2110183B Property

storage temp.: Store at -20°C, protect from light, stored under nitrogen
solubility: DMSO:65.0(Max Conc. mg/mL);140.15(Max Conc. mM)
DMF:50.0(Max Conc. mg/mL);107.81(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);107.81(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.08(Max Conc. mM)
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17988
Product name: Afuresertib (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 17988
Product name: Afuresertib (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 17988
Product name: Afuresertib (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $254
Updated: 2024/03/01

Cayman Chemical

Product number: 17988
Product name: Afuresertib (hydrochloride)
Packaging: 25mg
Price: $583
Updated: 2024/03/01

ChemScene

Product number: CS-3385
Product name: Afuresertib(hydrochloride)
Purity: 98.02%
Packaging: 100mg
Price: $564
Updated: 2021/12/16

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GSK2110183B Chemical Properties,Usage,Production

Uses

Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. It preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation and various cell lines derived from hematologic malignancies with minimal effect on glucose homeostasis. Afuresertib demonstrates activity against multiple myeloma in both preclinical and clinical models.[Cayman Chemical]

GSK2110183B Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK2110183B Suppliers

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1047645-82-8, GSK2110183BRelated Search:

Afuresertib (hydrochloride)

GSK 2110183B

GSK2110183B

GSK-2110183B

GSK 2110183 hydrochloride

GSK2110183 hydrochloride

GSK-2110183 hydrochloride

N-((S)-1-Amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride

Afuresertib HCl

Afuresertib HCl (GSK2110183)

Afuresertib HCl salt, GSK-2110183 HCl salt, GSK-2110183B HCl salt

N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

2-Thiophenecarboxamide, n-[(1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-, hydrochloride (1:1)

AFURESERTIB;GSK 2110183;GSK2110183;GSK 2110183 HYDROCHLORIDE; GSK2110183 HYDROCHLORIDE; GSK-2110183 HYDROCHLORIDE

GSK 2110183 hydrochloride - Afuresertib hydrochloride

(S)-N-(1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride

Afuresertib hydrochloride GSK2110183

Afuresertib,PKC,Protein kinase C,Akt,PKB,Rho-kinase,GSK2110183,ROK,Rho-associated protein kinase,Inhibitor,GSK-2110183,inhibit,Protein kinase B,Afuresertib hydrochloride,Rho-associated kinase,GSK 2110183,ROCK

(S)-N-(1-amino-3- (3-fluorophenyl) propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl) thiophene-2-formamide, hydrochloride

1047645-82-8

C18H17Cl2FN4OSClH