ChemicalBook > CAS DataBase List > b-AP15

b-AP15

Product Name
b-AP15
CAS No.
330450-45-8
Chemical Name
b-AP15
Synonyms
b-AP15;NSC-687852;NSC687852 >=98% (HPLC);(3Z,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-piperidin-4-one;4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-
CBNumber
CB02667632
Molecular Formula
C22H17N3O6
Formula Weight
419.39
MOL File
330450-45-8.mol
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b-AP15 Property

Boiling point:
670.4±55.0 °C(Predicted)
Density 
1.416±0.06 g/cm3(Predicted)
pka
-1.39±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4566
Product name
NSC687852
Purity
≥97%(HPLC)
Packaging
10
Price
$149
Updated
2021/12/16
Tocris
Product number
4566
Product name
NSC687852
Purity
≥97%(HPLC)
Packaging
50
Price
$549
Updated
2021/12/16
Usbiological
Product number
256062
Product name
NSC 687852
Packaging
10mg
Price
$403
Updated
2021/12/16
Ark Pharm
Product number
P000532871
Product name
b-AP15
Purity
98+%
Packaging
100mg
Price
$509
Updated
2021/12/16
Ark Pharm
Product number
P000532871
Product name
b-AP15
Purity
98+%
Packaging
250mg
Price
$814
Updated
2021/12/16
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b-AP15 Chemical Properties,Usage,Production

Enzyme inhibitor

This deubiquitinase inhibitor (FW = 421.31 g/mol; CAS 1009817-63-3), also named 3,5-bis[ (4-nitrophenyl) methylene]-1- (1-oxo-2-propen-1-yl) - (3E,5E) -4-piperidinone, targets two proteasome-associated ubiquitin carboxyl-terminal hydrolase-14, or USP14, and Ubiquitin Carboxyl-terminal Hydrolase isozyme L5 UCHL5, IC50 = 2.1 μM, resulting in a rapid accumulation of high-molecular-weight ubiquitin conjugates and functional shutdown of proteasome. Interestingly, b-AP15 displays several differences with respect to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in solid tumor models. Inhibition of DUBs blocked the processing and release of interleukin IL-1β in both mouse and human macrophages. DUB activity was necessary for inflammasome association as DUB inhibition also impaired ASC oligomerization and caspase-1 activation without directly blocking caspase- 1 activity. These data reveal the requirement for DUB activity in a key reaction of the innate immune response and highlight the therapeutic potential of DUB inhibitors for chronic auto-inflammatory diseases. (See also Bortezomib, Eeeyarestatin I)

b-AP15 Preparation Products And Raw materials

Raw materials

Preparation Products

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b-AP15 Suppliers

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330450-45-8, b-AP15Related Search:


  • b-AP15
  • NSC-687852
  • (3Z,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-piperidin-4-one
  • NSC687852 >=98% (HPLC)
  • 4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-
  • 330450-45-8
  • 1009817-63-4