ChemicalBook > CAS DataBase List > 5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride

5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride

Product Name
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride
CAS No.
1234015-54-3
Chemical Name
5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride
Synonyms
Prexasertib HCl;LY2606368 dihydrochloride;LY2606368 2HCL;LY 2606368;LY-2606368;LY-2606368 (Prexasertib);LY-2606368 dihydrochloride;Prexasertib dihydrochloride;Prexasertib HCl (LY2606368);Prexasertib (LY2606368) 2HCl;Prexasertib 2HCl (LY-2606368)
CBNumber
CB02669661
Molecular Formula
C18H21Cl2N7O2
Formula Weight
438.31104
MOL File
1234015-54-3.mol
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5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO:12.5(Max Conc. mg/mL);28.52(Max Conc. mM)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3507
Product name
Prexasertib(dihydrochloride)
Purity
99.41%
Packaging
5mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-3507
Product name
Prexasertib(dihydrochloride)
Purity
99.41%
Packaging
10mg
Price
$180
Updated
2021/12/16
ApexBio Technology
Product number
B8313
Product name
5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile hydrochloride
Packaging
5mg
Price
$220
Updated
2021/12/16
AK Scientific
Product number
4999DG
Product name
Prexasertibdihydrochloride
Packaging
50mg
Price
$316
Updated
2021/12/16
ApexBio Technology
Product number
B8313
Product name
5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile hydrochloride
Packaging
25mg
Price
$660
Updated
2021/12/16
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5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride Chemical Properties,Usage,Production

Description

Prexasertib HCl is a member of the serine/threonine protein kinase family and is the core protein of cell cycle checkpoints in DNA damage response (DDR).

Biological Activity

Prexasertib HCl is an ATP-competitive inhibitor of CHK1 with a Ki value of 0.9 nM. In cell-free experiments, the IC50 values of it for CHK2 and RSK were 8 nM and 9 nM, respectively.

target

< tr>
TargetValue
Chk1
(Cell-free assay)		 0.9 nM(Ki)
Chk2
(Cell-free assay)		 8 nM
RSK
(Cell-free assay)		 9 nM

5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride Suppliers

China 64 United States 7 Global 71
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1234015-54-3, 5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochlorideRelated Search:

L-LEUCYL-L-TYROSINE THZ1 (Hydrochloride) RMC6291

  • 5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile hydrochloride
  • 5-(5-(2-(3-aMinopropoxy)-6-Methoxyphenyl)-1H-pyrazol-3-ylaMino)pyrazine-2-carbonitrile dihydrochloride
  • LY2606368 dihydrochloride
  • LY-2606368 dihydrochloride
  • Prexasertib (LY2606368) 2HCl
  • Prexasertib HCl (LY2606368)
  • Prexasertib dihydrochloride
  • LY-2606368 (Prexasertib)
  • LY 2606368;LY-2606368
  • LY 2606368;LY-2606368;PREXASERTIB DIHYDROCHLORIDE
  • Prexasertib HCl
  • LY2606368 2HCL
  • Prexasertib 2HCl (LY-2606368)
  • Apoptosis,CDK2,Prexasertib,ARK5,replication,RSK1,inhibit,MELK,DNA,HeLa,LY 2606368,Inhibitor,Prexasertib dihydrochloride,HT-29,double-stranded,BRSK2,ATP-competitive,CDC25A,S296,S516,autophosphorylation,H2AX,LY-2606368,SIK,Checkpoint Kinase (Chk)
  • 1234015-54-3