AVE0991
- Product Name
- AVE0991
- CAS No.
- 304462-19-9
- Chemical Name
- AVE0991
- Synonyms
- AVE0991;N-(Ethylcarbamoyl)-3-(4-((5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl)phenyl)-5-isobutylthiophene-2-sulfonamide;N-[(Ethylamino)carbonyl]-3-[4-[(5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)-2-thiophenesulfonamide;2-Thiophenesulfonamide, N-[(ethylamino)carbonyl]-3-[4-[(5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)-
- CBNumber
- CB02669757
- Molecular Formula
- C29H32N4O5S2
- Formula Weight
- 580.72
- MOL File
- 304462-19-9.mol
AVE0991 Property
- Melting point:
- 191-192℃
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- ≥29.04 mg/mL in DMSO
- form
- solid
- pka
- 5.12±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 3460AH
- Product name
- N-(Ethylcarbamoyl)-3-(4-((5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl)phenyl)-5-isobutylthiophene-2-sulfonamide
- Packaging
- 10mg
- Price
- $224
- Updated
- 2021/12/16
- Product number
- B1007
- Product name
- AVE0991
- Packaging
- 5mg
- Price
- $238
- Updated
- 2021/12/16
- Product number
- CS-1752
- Product name
- AVE0991
- Purity
- 99.92%
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- B1007
- Product name
- AVE0991
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $315
- Updated
- 2021/12/16
- Product number
- 3460AH
- Product name
- N-(Ethylcarbamoyl)-3-(4-((5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl)phenyl)-5-isobutylthiophene-2-sulfonamide
- Packaging
- 50mg
- Price
- $338
- Updated
- 2021/12/16
AVE0991 Chemical Properties,Usage,Production
Biological Activity
ave 0991 is an agonist of angiotensin-(1-7) receptor [1].as an ang-(1–7) mimic, ave0991 acts as a nonpeptide agonist of angiotensin-(1-7) receptor. in water-loaded mice (c57bl/6), ave0991(0.58 nmol/g)produces a significant decrease of water dieresis. the antidiuretic effect of ave was associated with an increase in urine osmolality. it also occurs in water-loaded swiss mice. the antidiuretic action of ave can be blocked by the ang ii antagonists completely, demonstrating the specificity of ave 0991. since ang ii promotes atherogenesis and ang-(1–7) opposites ang ii action, it is reported that ave 0991 can inhibit atherogenesis in apolipoprotein e (apoe)-knockout mice model [1, 2].
in vitro
AVE 0991 is a nonpeptide compound that evokes effects similar to Ang-(1-7) on the endothelium. AVE 0991 and unlabeled Ang-(1-7) compete for high-affinity binding of [ 125 I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC 50 s of 21±35 and 220±280 nM, respectively . Peak concentrations of NO and O 2 - release by AVE 0991 sodium salt and Ang-(1-7) (both 10 μM) are not significantly different (NO: 295 ±20 and 270±25 nM; O 2 - : 18±2 and 20±4 nM). However, the released amount of bioactive NO is ≈5 times higher for AVE 0991 in comparison to Ang-(1-7).
target
angiotensin-(1-7) receptor
References
[1] sergio veloso brant pinheiro, ana cristina simoes e silva, walkyria oliveira sampaio, renata dutra de paula, elizabeth pereira mendes, elizabete dias bontempo, joao bosco pesquero, thomas walther, natalia alenina, michael bader, markus bleich, robson augusto souza santos. nonpeptide ave 0991 is an angiotensin-(1–7) receptor mas agonist in the mouse kidney. hypertension. 2004, 44: 490-496.
[2] j. toton-zuranska, m. gajda, g. pyka-fosciak, k. kus, m. pawlowska, a. niepsuj, p. wolkow, r. olszanecki, j. jawien, r. korbut. ave 0991- angiotensin-(1-7) receptor agonist, inhibits atherogenesis in apoe-knockout mice. journal of physiology and pharmacology. 2010, 61(2):181-183.