5-Carboxy-8-hydroxyquinoline

ChemicalBook > CAS DataBase List > 5-Carboxy-8-hydroxyquinoline

5-Carboxy-8-hydroxyquinoline

Product Name: 5-Carboxy-8-hydroxyquinoline
CAS No.: 5852-78-8
Chemical Name: 5-Carboxy-8-hydroxyquinoline
Synonyms: IOX1;8-Hydroxyquinoline-5-carboxylic Acid;CS-1524;IOX-1;IOX 1;IOX 1, >=98%;5-Carboxy-8-hydroxyquinoline;JMJD2 Inhibitor, 5-carboxy-8HQ;8-hydroxy-5-Quinolinecarboxylic acid;5-Quinolinecarboxylic acid, 8-hydroxy-;5-Carboxy-8-hydroxyquinoline USP/EP/BP
CBNumber: CB02671446
Molecular Formula: C10H7NO3
Formula Weight: 189.17
MOL File: 5852-78-8.mol

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5-Carboxy-8-hydroxyquinoline Property

Melting point:: 301 °C (decomp)
Boiling point:: 464.5±30.0 °C(Predicted)
Density: 1.480±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
pka: 1.82±0.10(Predicted)
form: powder
color: white to brown
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey: JGRPKOGHYBAVMW-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0067
Product name: IOX1
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $125
Updated: 2024/03/01

Sigma-Aldrich

Product number: 420201
Product name: JMJD2 Inhibitor, 5-carboxy-8HQ
Packaging: 5mg
Price: $209
Updated: 2023/01/07

Cayman Chemical

Product number: 11572
Product name: IOX1
Purity: ≥97%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 11572
Product name: IOX1
Purity: ≥97%
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0067
Product name: IOX1
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $200
Updated: 2024/03/01

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5-Carboxy-8-hydroxyquinoline Chemical Properties,Usage,Production

Description

IOX 1 (5852-78-8) inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively.1?A broad spectrum 2-oxoglutarate oxygenase inhibitor, IOX 1 may be used to study hypoxic signaling.1?Cell permeable

Uses

8-Hydroxyquinoline-5-carboxylic Acid is an inhibitor of KDM2/7 histone demethylase. 8-Hydroxyquinoline-5-carboxylic acid has also shown potential to be used as a regulator of plant growth.

Uses

IOX1 has been used:

To eliminate viral latency in latent viruses in order to sensitize the viral infections to antiviral therapy.
In histone lysine demethylase 4A (KDM4A) inhibition, to serve as a unique strategy to decrease hypoxia-inducible factors signalling.
to restore oncogene-induced senescence in wild-type mouse embryo fibroblasts.

Uses

5-Carboxy-8-hydroxyquinoline is an inhibitor of KDM2/7 histone demethylase. 5-Carboxy-8-hydroxyquinoline has also shown potential to be used as a regulator of plant growth.

Definition

ChEBI: 8-hydroxy-5-quinolinecarboxylic acid is a member of quinolines.

Biochem/physiol Actions

IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. For full characterization details, please visit the IOX1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at +4°C

References

1) King et al. (2010), Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors; PLoS One, 5 e15535

5-Carboxy-8-hydroxyquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Carboxy-8-hydroxyquinoline manufacturers

Career Henan Chemical Co

Product: 5-Carboxy-8-hydroxyquinoline 5852-78-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 85.0-99.8%
Supply Ability: 20 tons
Release date: 2019-12-23

5852-78-8, 5-Carboxy-8-hydroxyquinolineRelated Search:

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5-Carboxy-8-hydroxyquinoline

8-Hydroxyquinoline-5-carboxylic Acid

IOX1

8-hydroxy-5-Quinolinecarboxylic acid

IOX 1, >=98%

JMJD2 Inhibitor, 5-carboxy-8HQ

8-Hydroxyquinoline-5-carboxylic acid 95%

JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem

CS-1524

IOX-1;IOX 1

5-Quinolinecarboxylic acid, 8-hydroxy-

5-Carboxy-8-hydroxyquinoline USP/EP/BP

IOX-1, histone demethylase JMJD inhibitor

5852-78-8

Inhibitors

Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals

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