1-(4-BroMo-phenyl)-cyclobutanecarboxylic acid Methyl ester
- Product Name
- 1-(4-BroMo-phenyl)-cyclobutanecarboxylic acid Methyl ester
- CAS No.
- 1236357-65-5
- Chemical Name
- 1-(4-BroMo-phenyl)-cyclobutanecarboxylic acid Methyl ester
- Synonyms
- Methyl 1-(4-bromophenyl)cyclobutanecarboxylate;methyl 1-(4-bromophenyl)cyclobutane-1-carboxylate;Methyl 1-(4-bromophenyl)cyclobutanecarboxylate - [M15611];1-(4-BroMo-phenyl)-cyclobutanecarboxylic acid Methyl ester;Cyclobutanecarboxylic acid, 1-(4-bromophenyl)-, methyl ester
- CBNumber
- CB02671587
- Molecular Formula
- C12H13BrO2
- Formula Weight
- 269.13
- MOL File
- 1236357-65-5.mol
1-(4-BroMo-phenyl)-cyclobutanecarboxylic acid Methyl ester Property
- Boiling point:
- 308.6±35.0 °C(Predicted)
- Density
- 1.436±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Solid-Liquid Mixture
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M296765
- Product name
- Methyl1-(4-Bromophenyl)cyclobutanecarboxylate
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 124841
- Product name
- Methyl1-(4-bromophenyl)cyclobutanecarboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $594
- Updated
- 2021/12/16
- Product number
- OR914109
- Product name
- Methyl1-(4-bromophenyl)cyclobutane-1-carboxylate
- Packaging
- 5g
- Price
- $653
- Updated
- 2021/12/16
- Product number
- OR914109
- Product name
- Methyl1-(4-bromophenyl)cyclobutane-1-carboxylate
- Packaging
- 250mg
- Price
- $82
- Updated
- 2021/12/16
- Product number
- OR914109
- Product name
- Methyl1-(4-bromophenyl)cyclobutane-1-carboxylate
- Packaging
- 1g
- Price
- $203
- Updated
- 2021/12/16
1-(4-BroMo-phenyl)-cyclobutanecarboxylic acid Methyl ester Chemical Properties,Usage,Production
Synthesis
41841-16-1
109-64-8
1236357-65-5
1. Preparation of the intermediate 1-(4-bromophenyl)cyclobutanecarboxylic acid methyl ester (1AH-1): Sodium hydride (3.5 g, 88 mmol) was suspended in dimethylformamide (250 mL) under argon protection. The suspension was heated to 35 °C and a solution of methyl 2-(4-bromophenyl)acetate (10 g, 44 mmol) in dimethylformamide (100 mL) was slowly added dropwise over a period of 1 h. Subsequently, stirring was continued at 30 °C for 1 h. The solution of methyl 2-(4-bromophenyl)acetate (10 g, 44 mmol) was added dropwise over a period of 1 h. The solution was then stirred for 1 h at 30 °C. 2. A solution of dimethylformamide (50 mL) of 1,3-dibromopropane (4.4 mL, 44 mmol) was added dropwise to the above reaction mixture over a period of 1 h. The reaction mixture was then stirred overnight at room temperature. The reaction was not complete. 3. In another vessel, sodium hydride (3.5 g, 88 mmol) was suspended in dimethylformamide (100 mL) at 35 °C and this suspension was added dropwise to the reaction mixture over 1 hour. The reaction mixture was again stirred at room temperature overnight. 4. Upon completion of the reaction, the reaction was quenched by careful addition of saturated aqueous ammonium chloride solution (200 mL), followed by dilution with water (500 mL). The product was extracted with ethyl acetate (2 x 500 mL) and the organic phase was washed sequentially with water (3 x 500 mL) and brine (2 x 500 mL). 5. Combine the organic phases, dry with magnesium sulfate, filter and concentrate under reduced pressure. The crude product was purified by fast column chromatography (eluent: 12.5% ethyl acetate in heptane) to afford methyl 1-(4-bromophenyl)cyclobutanecarboxylate (900 mg, 3.3 mmol, 7.5% yield). 6. The structure of the product was determined by 1H NMR. 6. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.45 (d, 2H), 7.15 (d, 2H), 3.65 (s, 3H), 2.80 (m, 2H), 2.45 (m, 2H), 2.05 (m, 1H), 1.85 (m, 1H).
References
[1] Patent: WO2010/86820, 2010, A1. Location in patent: Page/Page column 54
[2] Patent: US2010/197591, 2010, A1. Location in patent: Page/Page column 32
1-(4-BroMo-phenyl)-cyclobutanecarboxylic acid Methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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